2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy-

Base Information

Chemical Name:2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy-
CAS No.:93632-84-9
Molecular Formula:C20H27N5O3
Molecular Weight:385.466
Hs Code.:
UNII:WSU6LPA0KS
DSSTox Substance ID:DTXSID601343081
Nikkaji Number:J1.030.670A
Wikidata:Q27292811

Synonyms:4-Hydroxycilostazol;OPC-13326;OPC 13326;UNII-WSU6LPA0KS;WSU6LPA0KS;93632-84-9;2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy-;SCHEMBL11038009;DTXSID601343081;Q27292811

Suppliers and Price of 2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy-

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:385.21138974
Heavy Atom Count:28
Complexity:516

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCC(CC1)N2C(=NN=N2)CCCCOC3=CC4=C(C=C3)NC(=O)CC4O

Technology Process of 2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy-

There total 6 articles about 2(1H)-Quinolinone, 6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-4-hydroxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 93662-05-6
ethyl 3-(5-<4-(1-cyclohexyl-1H-5-tetrazolyl)butoxy>-2-nitrophenyl)-3-hydroxypropionate

: 93632-84-9
OPC-13326

Guidance literature:: With ammonium hydroxide; iron(II) sulfate; In ethanol; water; at 50 - 60 ℃; for 1.5h;
DOI:10.1248/cpb.33.1140

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 93632-84-9
OPC-13326

Guidance literature:: Multi-step reaction with 5 steps

1: 66 percent / triethylorthoformate, TsOH / 1 h / Heating

2: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 120 °C

3: 86 percent / 2 N HCl / tetrahydrofuran / 1 h / 50 °C

4: 1) n-BuLi, diisopropylamine / 1) hexane, THF, toluene, -60 deg; 2) hexane, toluene, THF, -60 deg C -->room temp.

5: 48 percent / 28percent aq.NH₄OH, FeSO₄*7H₂O / ethanol; H₂O / 1.5 h / 50 - 60 °C

With hydrogenchloride; ammonium hydroxide; n-butyllithium; potassium carbonate; toluene-4-sulfonic acid; iron(II) sulfate; diisopropylamine; orthoformic acid triethyl ester; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1140

Reference yield:

: 98454-56-9
5-hydroxy-2-nitrobenzaldehyde ethylene acetal

: 93632-84-9
OPC-13326

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / K₂CO₃ / dimethylformamide / 6 h / 120 °C

2: 86 percent / 2 N HCl / tetrahydrofuran / 1 h / 50 °C

3: 1) n-BuLi, diisopropylamine / 1) hexane, THF, toluene, -60 deg; 2) hexane, toluene, THF, -60 deg C -->room temp.

4: 48 percent / 28percent aq.NH₄OH, FeSO₄*7H₂O / ethanol; H₂O / 1.5 h / 50 - 60 °C

With hydrogenchloride; ammonium hydroxide; n-butyllithium; potassium carbonate; iron(II) sulfate; diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1248/cpb.33.1140