Synonyms:sulfuryl diazide;sulfonyl azide;sulfonylazide;72250-07-8;HSVFKFNNMLUVEY-UHFFFAOYSA-N;DTXSID401336969;Q18651988
The research focuses on the development of an efficient approach to synthesize fused indolines, which are important structural motifs found in a variety of natural products and biologically active compounds. The study describes a cascade reaction involving 2-ethynylaryl methylenecyclopropane and sulfonyl azide, catalyzed by copper(I) iodide under mild conditions. This novel method provides a rapid and efficient route for generating fused indolines. The experiments involved optimizing reaction conditions, including the choice of copper catalyst, base, and solvent, with triethylamine and 1,4-dioxane being the most effective. The reaction's scope was explored with variously substituted reactants, and the products were analyzed using X-ray diffraction, NMR spectroscopy, and other characterization techniques to confirm their structures. The results demonstrated the versatility and efficiency of the method, with yields ranging from moderate to high depending on the substituents on the reactants.
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