(E)-2-(3,4-dimethoxystyryl)-4H-benzo[d][1,3]oxazin-4-one

Base Information

• Chemical Name: (E)-2-(3,4-dimethoxystyryl)-4H-benzo[d][1,3]oxazin-4-one
• CAS No.: 93755-78-3
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.321
• DSSTox Substance ID: DTXSID801173218
• Nikkaji Number: J1.227.688E
• Mol file: 93755-78-3.mol

Synonyms:SCHEMBL1589852;SCHEMBL1589854;ZWWUBZYDOACBQC-CSKARUKUSA-N;DTXSID801173218;(E)-2-(3,4-dimethoxystyryl)-4H-benzo[d][1,3]oxazin-4-one;2-[2-(3,4-Dimethoxyphenyl)ethenyl]-4H-3,1-benzoxazine-4-one;2-[(1E)-2-(3,4-Dimethoxyphenyl)ethenyl]-4H-3,1-benzoxazin-4-one;93755-78-3

Chemical Property of (E)-2-(3,4-dimethoxystyryl)-4H-benzo[d][1,3]oxazin-4-one

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 309.10010796
• Heavy Atom Count: 23
• Complexity: 487

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C=CC2=NC3=CC=CC=C3C(=O)O2)OC
• Isomeric SMILES: COC1=C(C=C(C=C1)/C=C/C2=NC3=CC=CC=C3C(=O)O2)OC

Technology Process of (E)-2-(3,4-dimethoxystyryl)-4H-benzo[d][1,3]oxazin-4-one

There total 4 articles about (E)-2-(3,4-dimethoxystyryl)-4H-benzo[d][1,3]oxazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Tranilast (70806-55-2) → 2-(3,4-dimethoxy-trans-styryl)-benzo[d][1,3]oxazin-4-one (93755-78-3)

Guidance literature:

With 2-chloro-1,3-dimethylimidazolinium chloride; triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1021/jo9909756

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-(3,4-dimethoxy-trans-styryl)-benzo[d][1,3]oxazin-4-one (93755-78-3)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 3 h / Reflux

2: piperidine / toluene / 4 h / Reflux

3: acetic anhydride / 3 h / Reflux

With piperidine; acetic anhydride; In toluene;

Reference yield:

2-[(2-carboxyacetyl)amino]benzoic acid (53947-84-5) → 2-(3,4-dimethoxy-trans-styryl)-benzo[d][1,3]oxazin-4-one (93755-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: piperidine / toluene / 4 h / Reflux

2: acetic anhydride / 3 h / Reflux

With piperidine; acetic anhydride; In toluene;

upstream raw materials:

Tranilast

anthranilic acid

2-[(2-carboxyacetyl)amino]benzoic acid