Technology Process of 8a(1H)-Isoquinolinecarboxylic acid,
5-[2-(acetyloxy)phenoxy]-2,3,4,6,7,8-hexahydro-2-methyl-1,6-dioxo-,
methyl ester
There total 11 articles about 8a(1H)-Isoquinolinecarboxylic acid,
5-[2-(acetyloxy)phenoxy]-2,3,4,6,7,8-hexahydro-2-methyl-1,6-dioxo-,
methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
2: acetic acid, water, sodium acetate / benzene / 1.5 h / Heating
3: 69 percent / 30percent H2O2, aq. NaOH / methanol / 2.5 h / 10 - 20 °C
4: 46 percent / KH / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) RT, 3.5 h, 2.) reflux, 25 h
5: 1.) H2, 2.) pyridine / 1.) 5percent Pd/C / 1.) ethyl acetate, 1 atm, 5 h, 2.) CH2Cl2, RT, 12 h
With
pyridine; sodium hydroxide; water; hydrogen; dihydrogen peroxide; sodium acetate; potassium hydride; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; benzene;
DOI:10.1021/jo00202a014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: NaH / benzene; ethanol
3: acetic acid, water, sodium acetate / benzene / 1.5 h / Heating
4: 69 percent / 30percent H2O2, aq. NaOH / methanol / 2.5 h / 10 - 20 °C
5: 46 percent / KH / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) RT, 3.5 h, 2.) reflux, 25 h
6: 1.) H2, 2.) pyridine / 1.) 5percent Pd/C / 1.) ethyl acetate, 1 atm, 5 h, 2.) CH2Cl2, RT, 12 h
With
pyridine; sodium hydroxide; water; hydrogen; dihydrogen peroxide; sodium acetate; potassium hydride; sodium hydride; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; benzene;
DOI:10.1021/jo00202a014
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) Mg / 1.) THF, 2 h, 2.) RT, 30 min
2: Na2Cr2O7/H2SO4 (Jones reagent) / acetone / 0.08 h / 0 °C
3: 86 percent / KOH / methanol; benzene / 48 h / Ambient temperature
4: 21 percent / KH / benzene; dioxane / 12 h / Heating
5: 1.) H2, 2.) pyridine / 1.) 5percent Pd/C / 1.) ethyl acetate, 1 atm, 5 h, 2.) CH2Cl2, RT, 12 h
With
pyridine; potassium hydroxide; sodium dichromate; sulfuric acid; hydrogen; potassium hydride; magnesium;
palladium on activated charcoal;
In
1,4-dioxane; methanol; acetone; benzene;
DOI:10.1021/jo00202a014
