Hydroxy(2-naphthyl)Methanephosphonic Acid

Base Information

Chemical Name:Hydroxy(2-naphthyl)Methanephosphonic Acid
CAS No.:132541-52-7
Molecular Formula:C11H11O4P
Molecular Weight:238.18
Hs Code.:
Mol file:132541-52-7.mol

Synonyms:OH-Name-PA;(hydroxy-naphthalen-2-yl-methyl)phosphonic acid;

Suppliers and Price of Hydroxy(2-naphthyl)Methanephosphonic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Hydroxy(2-naphthyl)methanephosphonicAcid
100mg
$ 630.00

TRC
Hydroxy(2-naphthyl)methanephosphonicAcid
10mg
$ 105.00

Cayman Chemical
HNMPA ≥95%
5mg
$ 63.00

Cayman Chemical
HNMPA ≥95%
1mg
$ 25.00

Cayman Chemical
HNMPA ≥95%
25mg
$ 250.00

Cayman Chemical
HNMPA ≥95%
10mg
$ 113.00

ApexBio Technology
HNMPA
25mg
$ 347.00

ApexBio Technology
HNMPA
10mg
$ 158.00

Total 2 raw suppliers

Chemical Property of Hydroxy(2-naphthyl)Methanephosphonic Acid

Chemical Property:

Boiling Point:527.2°Cat760mmHg
Flash Point:272.6°C
PSA：87.57000
Density:1.514g/cm³
LogP:2.00840
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO, Methanol

Purity/Quality:

≥95% ^*data from raw suppliers

Hydroxy(2-naphthyl)methanephosphonicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description HNMPA is a cell impermeable tyrosine kinase inhibitor that blocks receptor serine and tyrosine phosphorylation, including insulin receptor tyrosine kinase activity. It does not affect protein kinase C or cyclic AMP-dependent protein kinase activities. HNMPA inhibits the insulin-stimulated autophosphorylation of the 95-kDa β-subunit of the insulin receptor with an IC50 value of 200 μM in vitro.
Uses Insulin receptor tyrosine kinase (IRTK) inhibitor. A selective insulin receptor tyrosine kinase inhibitor

Technology Process of Hydroxy(2-naphthyl)Methanephosphonic Acid

There total 4 articles about Hydroxy(2-naphthyl)Methanephosphonic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 132541-51-6
bis(2,2-dimethylethyl) (2-naphthalenylhydroxymethyl)phosphonate

: 132541-52-7
hydroxy-2-naphthalenylmethylphosphonic acid

Guidance literature:: With methoxybenzene; trifluoroacetic acid; for 1h; Ambient temperature;
DOI:10.1021/jm00109a008

Reference yield:

: 66-99-9
β-naphthaldehyde

: 132541-52-7
hydroxy-2-naphthalenylmethylphosphonic acid

Guidance literature:: β-naphthaldehyde; With t-butylphosphite bound on the Wang resin A; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; for 0.5h;

With trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1016/S0960-894X(02)00140-3