methyl 2-cyano-3-[1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl]acrylate

Base Information

Chemical Name:methyl 2-cyano-3-[1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl]acrylate
CAS No.:94008-43-2
Molecular Formula:C₁₁H₁₂N₂O₄S
Molecular Weight:268.293
Hs Code.:
Mol file:94008-43-2.mol

Synonyms:(E)-2-Cyano-3-(5-methanesulfonyl-1-methyl-1H-pyrrol-2-yl)-acrylic acid methyl ester;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-cyano-3-[1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl]acrylate

Chemical Property:

Melting Point:187 °C (ethanol)
PSA：97.54000
LogP:1.58938

Purity/Quality:

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Technology Process of methyl 2-cyano-3-[1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl]acrylate

There total 4 articles about methyl 2-cyano-3-[1-methyl-5-(methylsulfonyl)-1H-pyrrol-2-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 94008-40-9
2-Cyano-3-(1-methyl-5-methylthio-2-pyrrolyl)acrylic acid methyl ester

: 94008-43-2
2-Cyano-3-(1-methyl-5-methylsulfonyl-2-pyrrolyl)acrylic acid methyl ester

Guidance literature:: With dihydrogen peroxide; In acetic acid; for 120h; Ambient temperature;

Reference yield:

: 96-54-8
N-Methylpyrrole

: 94008-43-2
2-Cyano-3-(1-methyl-5-methylsulfonyl-2-pyrrolyl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: n-Butyllithium, tetramethylenediamine / 1) Ether, hexane, 30 min, reflux, 2) room temperature, 2 h.

2: 1) Phosphorus oxychloride, 3) sodium acetate / 1) 15 min, room temperature, 2) dichloroethane, reflux, 15 min, 3) reflux 15 min.

3: 73 percent / 10percent Sodium ethoxide / ethanol / 1 h

4: 74 percent / 30percent Hydrogen peroxide / acetic acid / 120 h / Ambient temperature

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; sodium ethanolate; sodium acetate; trichlorophosphate; In ethanol; acetic acid;

Reference yield:

: 73671-59-7
1-methyl-2-methylthiopyrrole

: 94008-43-2
2-Cyano-3-(1-methyl-5-methylsulfonyl-2-pyrrolyl)acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Phosphorus oxychloride, 3) sodium acetate / 1) 15 min, room temperature, 2) dichloroethane, reflux, 15 min, 3) reflux 15 min.

2: 73 percent / 10percent Sodium ethoxide / ethanol / 1 h

3: 74 percent / 30percent Hydrogen peroxide / acetic acid / 120 h / Ambient temperature

With dihydrogen peroxide; sodium ethanolate; sodium acetate; trichlorophosphate; In ethanol; acetic acid;