5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-((2-butoxyphenyl)amino)-4-oxo-

Base Information

Chemical Name:5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-((2-butoxyphenyl)amino)-4-oxo-
CAS No.:98772-04-4
Molecular Formula:C15H17N3O4
Molecular Weight:303.3132
Hs Code.:
DSSTox Substance ID:DTXSID10243800
Wikidata:Q83127969

Synonyms:BRN 5602458;1,6-Dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid;5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-((2-butoxyphenyl)amino)-4-oxo-;1,4-Dihydro-2-((2-butoxyphenyl)amino)-4-oxo-5-pyrimidinecarboxylic acid;98772-04-4;SCHEMBL10784690;DTXSID10243800;JRNZIFCRRQMVAK-UHFFFAOYSA-N;LS-134847

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-((2-butoxyphenyl)amino)-4-oxo-

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.32g/cm³
XLogP3:2.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:303.12190603
Heavy Atom Count:22
Complexity:487

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCOC1=CC=CC=C1NC2=NC=C(C(=O)N2)C(=O)O

Technology Process of 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-((2-butoxyphenyl)amino)-4-oxo-

There total 3 articles about 5-Pyrimidinecarboxylic acid, 1,4-dihydro-2-((2-butoxyphenyl)amino)-4-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 98771-58-5
ethyl 1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylate

: 98772-04-4
1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; at 80 ℃; for 2h;
DOI:10.1248/cpb.37.1780

Reference yield:

: 7252-51-9
n-butyl o-nitrophenyl ether

: 98772-04-4
1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 10percent Pd/C / methanol

2: 84 percent / 2 h / 130 °C

3: 73 percent / 4percent aq. NaOH / methanol / 2 h / 80 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1248/cpb.37.1780

Reference yield:

: 4469-81-2
2-butoxyaniline

: 98772-04-4
1,6-dihydro-2-(2-butoxyanilino)-6-oxo-5-pyrimidinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 2 h / 130 °C

2: 73 percent / 4percent aq. NaOH / methanol / 2 h / 80 °C

With sodium hydroxide; In methanol;
DOI:10.1248/cpb.37.1780