2-amino-7-(2,3-dihydroxypropyl)-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Base Information

Chemical Name:2-amino-7-(2,3-dihydroxypropyl)-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide
CAS No.:127945-65-7
Molecular Formula:C₁₁H₁₅N₅O₄S
Molecular Weight:313.337
Hs Code.:
Mol file:127945-65-7.mol

Synonyms:1H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide,2-amino-7-(2,3-dihydroxypropyl)-4,7-dihydro-6-(methylthio)-4-oxo- (9CI);1H-Pyrrolo[2,3-d]pyrimidine-5-carboxamide,2-amino-7-(2,3-dihydroxypropyl)-4,7-dihydro-6-(methylthio)-4-oxo-, (?à)-

Suppliers and Price of 2-amino-7-(2,3-dihydroxypropyl)-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 2 raw suppliers

Chemical Property of 2-amino-7-(2,3-dihydroxypropyl)-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

Chemical Property:

Vapor Pressure:4.5E-10mmHg at 25°C
Boiling Point:481.3°Cat760mmHg
Flash Point:244.9°C
Density:1.85g/cm³

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-amino-7-(2,3-dihydroxypropyl)-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide

There total 3 articles about 2-amino-7-(2,3-dihydroxypropyl)-6-(methylsulfanyl)-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 127945-49-7
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(RS)-2,3-O-isopropylidene-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

: 127945-65-7
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(RS)-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: With acetic acid; at 80 ℃; for 4h;
DOI:10.1021/jm00170a019

Reference yield:

: 38187-09-6
2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)pyrrole

: 127945-65-7
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(RS)-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) 100 deg C, 18 h

3: 58 percent / 80percent aq. AcOH / 4 h / 80 °C

With sodium hydride; acetic acid;
DOI:10.1021/jm00170a019

Reference yield:

: 127945-33-9
2-amino-3,4-bis(aminocarbonyl)-5-(methylthio)-1-<(RS)-2,3-O-isopropylidene-2,3-dihydroxypropyl>pyrrole

: 127945-65-7
2-amino-5-(aminocarbonyl)-6-(methylthio)-7-<(RS)-2,3-dihydroxypropyl>pyrrolo<2,3-d>pyrimidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

2: 58 percent / 80percent aq. AcOH / 4 h / 80 °C

With acetic acid;
DOI:10.1021/jm00170a019