(E)-3-(furan-2-yl)acrylic acid

Base Information

• Chemical Name: (E)-3-(furan-2-yl)acrylic acid
• CAS No.: 15690-24-1
• Molecular Formula: C₇H₆O₃
• Molecular Weight: 138.123
• Mol file: 15690-24-1.mol

Synonyms:(E)-3-(2-Furyl)acrylic acid;(E)-3-(2-Furyl)propenoic acid;(E)-3-(Furan-2-yl)-2-propenoic acid;(E)-3-(Furan-2-yl)acrylic acid;NSC 74521;trans-2-Furanacrylic acid;trans-3-(2-Furanyl)-2-propenoic acid;trans-b-2-Furylacrylic acid;2-Furanacrylicacid, (E)- (8CI);2-Propenoic acid, 3-(2-furanyl)-, (E)-;(2E)-3-(2-Furanyl)-2-propenoic acid;(2E)-3-(2-Furyl)-2-propenoic acid;(2E)-3-(Furan-2-yl)prop-2-enoic acid;

Chemical Property of (E)-3-(furan-2-yl)acrylic acid

Chemical Property:

• Boiling Point: 286 °C at 760 mmHg
• Flash Point: 106.8 °C
• PSA: 50.44000
• Density: 1.28 g/cm³
• LogP: 1.37740
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-(2-Furyl)acrylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-(furan-2-yl)acrylic acid

There total 45 articles about (E)-3-(furan-2-yl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

furfural (98-01-1) + malonic acid (141-82-2) → 3-(fur-2-yl)crotonic acid (539-47-9,15690-24-1)

Guidance literature:

furfural; malonic acid; With piperidine; pyridine; at 20 - 100 ℃; for 3h;

With hydrogenchloride; In water;

Reference yield: 90.0%

ethyl (E)-3-(2-furyl)prop-2-enoate (53282-12-5,53282-26-1) → 3-(fur-2-yl)crotonic acid (539-47-9,15690-24-1)

Guidance literature:

With potassium hydroxide; for 4h; Heating;

DOI:10.1002/chem.200501034

Reference yield: 82.0%

furfural (98-01-1) + diethylphosphonoacetic acid (3095-95-2) → 3-(fur-2-yl)crotonic acid (539-47-9,15690-24-1)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; zinc trifluoromethanesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1055/s-2006-950292

upstream raw materials:

furfural

Ketene

N-acetylpropionamide

sodium acetate

Downstream raw materials:

2-fluoro-4-nitro-N-(3-(tetrahydrofuran-2-yl)propyl)aniline

2-fluoro-N¹-(3-(tetrahydrofuran-2-yl)propyl)benzene-1,4-diamine

4-(1-piperazinyl)furo<3,2-c>pyridine

N-<3-(2-furyl)acryloyl>-Gly

Refernces

• 1、 Mori, Akira,Takeshita, Hitoshi. "Synthetic Photochemistry XXXVIII. The Photorearrangement of the Tropone Endoperoxide, 6,7-Dioxabicyclo-nona-3,8-dien-2-one". . p. 3037 - 3038. Retrieved 1987.
• 2、 Swamy, Ponnapalli Veerabhadra,Kambhampati, Pullaiah China,Chandrasekhar, Kothapalli Bonnoth,Thirupathi, Gugulothu,Sujitha, Pombala,Kumar, Chityal Ganesh,Kumar, Veeramachaneni Ganesh. "Synthesis, biological evaluation and molecular docking studies of some novel cyclopropane carbohydrazide derivatives as potential anticancer agents". . p. 929 - 939. Retrieved 2016.
• 3、 Das, Aniruddha,Anbu, Nagaraj,Gogoi, Chiranjib,Dhakshinamoorthy, Amarajothi,Biswas, Shyam. "Amino Group Functionalized Hf-Based Metal-Organic Framework for Knoevenagel-Doebner Condensation". . p. 3396 - 3403. Retrieved 2021/08/20.