4-(2-Bromoacetyl)benzene-1-sulfonamide

Base Information

• Chemical Name: 4-(2-Bromoacetyl)benzene-1-sulfonamide
• CAS No.: 944-33-2
• Molecular Formula: C8H8BrNO3S
• Molecular Weight: 278.126
• European Community (EC) Number: 879-037-7
• Mol file: 944-33-2.mol

Synonyms:4-(2-bromoacetyl)benzene-1-sulfonamide;944-33-2;4-(bromoacetyl)benzenesulfonamide;4-(2-bromoacetyl)benzenesulfonamide;Benzenesulfonamide, 4-(bromoacetyl)-;4-bromoacetylbenzenesulphonamide;SCHEMBL3642480;CYXRPWCLRVINRW-UHFFFAOYSA-N;MFCD08689427;AKOS005264060;BS-13967;CS-0248124;FT-0745496;EN300-39186;E78708;Z382690836

Chemical Property of 4-(2-Bromoacetyl)benzene-1-sulfonamide

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 276.94083
• Heavy Atom Count: 14
• Complexity: 301

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C(=O)CBr)S(=O)(=O)N

Technology Process of 4-(2-Bromoacetyl)benzene-1-sulfonamide

There total 2 articles about 4-(2-Bromoacetyl)benzene-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-acetylbenzenesulfonamide (1565-17-9) → 2-bromo-4'-aminosulfonylacetophenone (944-33-2)

Guidance literature:

With bromine; dibenzoyl peroxide; In methanol; water;

Reference yield:

→ 2-bromo-4'-aminosulfonylacetophenone (944-33-2)

Guidance literature:

4-Sulfamoyl-acetophenon 1. AlCl3, 0grad 2. Br2;

Reference yield: 91.0%

2-bromo-4'-aminosulfonylacetophenone (944-33-2) + ethyl 5-oxo-1-phenyl-4,5-dihydro-1H-1,2,4-triazole-3-carboxylate (67267-08-7) → ethyl 5-oxo-4-(2-oxo-2-(4-sulfamoylphenyl)ethyl)-1-phenyl-4,5-dihydro-1H-1,2,4-triazolo-3-carboxylate

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.ejmech.2020.112478

upstream raw materials:

4-acetylbenzenesulfonamide

Downstream raw materials:

C₁₁H₁₃NO₃S₄

4-(2-aminothiazol-4-yl)benzenesulfonamide hydrobromide

4-{[(4-tert-butyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide

4-{[(5-benzyl-4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide