Technology Process of 2-fluorolinalyl pyrophosphate
There total 4 articles about 2-fluorolinalyl pyrophosphate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(±)-2-fluoro-3,7-dimethylocta-1,6-dien-3-ol;
With
(1,2-dibromo-1-phenyl-ethyl)-phosphonic acid; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 24h;
With
trichloroacetonitrile; bis(tetra-n-butylammonium) hydrogen phosphate;
In
acetonitrile;
at 20 ℃;
for 24h;
DOI:10.1021/bi400797c
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 2,4,6-trimethyl-pyridine; water / acetone / 3 h / 60 °C
2.1: N-ethyl-N,N-diisopropylamine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid / dichloromethane / 24 h / 20 °C
2.2: 24 h / 20 °C
With
2,4,6-trimethyl-pyridine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid; water; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; acetone;
DOI:10.1021/bi400797c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: diisobutylaluminium hydride / toluene / 12 h / 20 °C
2.1: triethylamine / dichloromethane / 1 h / 0 °C
3.1: 2,4,6-trimethyl-pyridine; water / acetone / 3 h / 60 °C
4.1: N-ethyl-N,N-diisopropylamine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid / dichloromethane / 24 h / 20 °C
4.2: 24 h / 20 °C
With
2,4,6-trimethyl-pyridine; (1,2-dibromo-1-phenyl-ethyl)-phosphonic acid; water; diisobutylaluminium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; acetone; toluene;
DOI:10.1021/bi400797c
