Technology Process of 1,3-Benzodioxole, 5-[2-methoxy-1-(3,4,5-trimethoxyphenyl)ethenyl]-,
(E)-
There total 9 articles about 1,3-Benzodioxole, 5-[2-methoxy-1-(3,4,5-trimethoxyphenyl)ethenyl]-,
(E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tert.-butyl lithium; magnesium bromide;
In
diethyl ether; pentane;
1.) -78 deg C, 45 min, 2.) reflux, 5 d;
DOI:10.1021/jo00207a034
- Guidance literature:
-
Multi-step reaction with 7 steps
1: Br2, acetic acid
2: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C, 1.5 h
3: chromium trioxide, H2SO4 / acetone / 0.5 h / -20 °C
4: 97 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 - 25 °C
5: 62 percent / MgBr2 / diethyl ether / 0.5 h / 25 °C
6: 100 percent / p-toluenesulfonic acid / methanol; benzene / 50 h / 50 °C
7: 53 percent / MgBr2, t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 45 min, 2.) reflux, 5 d
With
chromium(VI) oxide; n-butyllithium; sulfuric acid; bromine; tert.-butyl lithium; toluene-4-sulfonic acid; acetic acid; magnesium bromide;
In
tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; acetone; pentane; benzene;
DOI:10.1021/jo00207a034
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) NaH, MeOH, 2.) N-bromosuccinimide / 1.) chloroform, 2.) -45 to -35 deg C
2: 80 percent / aq. NaOH / 6 h / Heating
3: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) -78 deg C, 1.5 h
4: chromium trioxide, H2SO4 / acetone / 0.5 h / -20 °C
5: 97 percent / dimethylsulfoxide; tetrahydrofuran / 1 h / 0 - 25 °C
6: 62 percent / MgBr2 / diethyl ether / 0.5 h / 25 °C
7: 100 percent / p-toluenesulfonic acid / methanol; benzene / 50 h / 50 °C
8: 53 percent / MgBr2, t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 45 min, 2.) reflux, 5 d
With
chromium(VI) oxide; methanol; sodium hydroxide; N-Bromosuccinimide; n-butyllithium; sulfuric acid; tert.-butyl lithium; sodium hydride; toluene-4-sulfonic acid; magnesium bromide;
In
tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide; acetone; pentane; benzene;
DOI:10.1021/jo00207a034
