(2S)-2-iodo-2-[(4aS,8aR)-octahydro-2H-chromen-2-yl]ethyl 2,4-dichlorobenzoate

Base Information

• Chemical Name: (2S)-2-iodo-2-[(4aS,8aR)-octahydro-2H-chromen-2-yl]ethyl 2,4-dichlorobenzoate
• CAS No.: 101859-02-3
• Molecular Formula: C18H21 Cl2 I O3
• Molecular Weight: 483.168
• Mol file: 101859-02-3.mol

Synonyms:

Chemical Property of (2S)-2-iodo-2-[(4aS,8aR)-octahydro-2H-chromen-2-yl]ethyl 2,4-dichlorobenzoate

Chemical Property:

• Vapor Pressure: 1.22E-10mmHg at 25°C
• Boiling Point: 513.1°Cat760mmHg
• Flash Point: 264.1°C
• Density: 1.558g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2S)-2-iodo-2-[(4aS,8aR)-octahydro-2H-chromen-2-yl]ethyl 2,4-dichlorobenzoate

There total 13 articles about (2S)-2-iodo-2-[(4aS,8aR)-octahydro-2H-chromen-2-yl]ethyl 2,4-dichlorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

2,4-Dichloro-benzoic acid (E)-5-[(1S,2R)-2-(4-bromo-benzyloxy)-cyclohexyl]-pent-2-enyl ester (101859-01-2) → (1R*,3S*,6S*)-3-((1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-iodoethyl)-2-oxabicyclo<4.4.0>decane (101859-03-4) + (1R*,3R*,6S*)-3-<(1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-iodoethyl>-2-oxabicyclo<4.4.0>decane (101859-02-3)

Guidance literature:

With iodine; In acetonitrile; at 0 ℃; for 21h;

DOI:10.1021/jo00362a014

Reference yield:

2,4-Dichloro-benzoic acid (E)-5-((1S,2R)-2-benzyloxy-cyclohexyl)-pent-2-enyl ester (101859-44-3) → (1R*,3S*,6S*)-3-((1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-iodoethyl)-2-oxabicyclo<4.4.0>decane (101859-03-4) + (1R*,3R*,6S*)-3-<(1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-iodoethyl>-2-oxabicyclo<4.4.0>decane (101859-02-3)

Guidance literature:

With iodine; In acetonitrile; at 0 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00362a014

Reference yield:

2,4-Dichloro-benzoic acid (E)-5-{(1S,2R)-2-[bis-(4-chloro-phenyl)-methoxy]-cyclohexyl}-pent-2-enyl ester (101859-56-7) → (1R*,3S*,6S*)-3-((1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-iodoethyl)-2-oxabicyclo<4.4.0>decane (101859-03-4) + (1R*,3R*,6S*)-3-<(1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-iodoethyl>-2-oxabicyclo<4.4.0>decane (101859-02-3)

Guidance literature:

With iodine; In acetonitrile; at 0 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00362a014

upstream raw materials:

2,4-Dichloro-benzoic acid (E)-5-((1S,2R)-2-benzyloxy-cyclohexyl)-pent-2-enyl ester

2,4-Dichloro-benzoic acid (E)-5-[(1S,2R)-2-(4-bromo-benzyloxy)-cyclohexyl]-pent-2-enyl ester

2,4-Dichloro-benzoic acid (E)-5-{(1S,2R)-2-[bis-(4-chloro-phenyl)-methoxy]-cyclohexyl}-pent-2-enyl ester

cyclohexane-1,2-epoxide

Downstream raw materials:

(1R*,3R*,6S*)-3-<(1S*)-1-((2,4-dichlorobenzoyl)oxy)-2-hydroxyethyl>-2-oxabicyclo<4.4.0>decane

(1R*,3R*,6S*)-3-<(1S*)-2-((2,4-dichlorobenzoyl)oxy)-1-hydroxyethyl>-2-oxabicyclo<4.4.0>decane

(1R*,3R*,4S*,7S*)-3-(((2,4-dichlorobenzoyl)oxy)-methyl)-4-(formyloxy)-2-oxabicyclo<5.4.0>undecane