Technology Process of 5-fluorobenzo[h]quinoline
There total 7 articles about 5-fluorobenzo[h]quinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
5-aminobenzo[h]quinoline;
With
tetrafluoroboric acid; sodium nitrite;
In
water;
at 0 ℃;
for 0.166667h;
With
1-ethyl-3-methylimidazolium tetrafluoroborate;
at 90 ℃;
for 24h;
Schlenk technique;
Inert atmosphere;
With
N-ethyl-N,N-diisopropylamine;
for 1h;
Schlenk technique;
Inert atmosphere;
DOI:10.1002/adsc.201800286
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: N-Bromosuccinimide; sulfuric acid / 35 °C
2.1: sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.17 h / 150 °C / Microwave irradiation; Inert atmosphere
3.1: hydrogenchloride / tetrahydrofuran; water / Inert atmosphere
4.1: ammonium hydroxide / water / pH 8
5.1: tetrafluoroboric acid; sodium nitrite / water / 0.17 h / 0 °C
5.2: 24 h / 90 °C / Schlenk technique; Inert atmosphere
5.3: 1 h / Schlenk technique; Inert atmosphere
With
hydrogenchloride; ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium(0); N-Bromosuccinimide; tetrafluoroboric acid; sulfuric acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; sodium nitrite;
In
tetrahydrofuran; water; toluene;
2.1: |Buchwald-Hartwig Coupling / 5.1: |Balz-Schiemann Reaction / 5.2: |Balz-Schiemann Reaction / 5.3: |Balz-Schiemann Reaction;
DOI:10.1002/adsc.201800286
![5-aminobenzo[h]quinoline](/Databaselist/images/loading.webp)
