1,1-Cyclohexanedicarboxylic acid, 3,4-bis(methylene)-, diethyl ester

Base Information

• Chemical Name: 1,1-Cyclohexanedicarboxylic acid, 3,4-bis(methylene)-, diethyl ester
• CAS No.: 94922-20-0
• Molecular Formula: C14H20O4
• Molecular Weight: 252.31
• Mol file: 94922-20-0.mol

Synonyms:

Chemical Property of 1,1-Cyclohexanedicarboxylic acid, 3,4-bis(methylene)-, diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1-Cyclohexanedicarboxylic acid, 3,4-bis(methylene)-, diethyl ester

There total 8 articles about 1,1-Cyclohexanedicarboxylic acid, 3,4-bis(methylene)-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-allyl-2-buta-2,3-dienyl-malonic acid diethyl ester → diethyl 3,4-bis(methylene)cyclohexane-1,1-dicarboxylate (94922-20-0)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; bis[2-(diphenylphosphino)phenyl] ether; In 1,2-dichloro-ethane; at 80 ℃; for 20h; regioselective reaction;

DOI:10.1039/c9sc00980a

Reference yield: 55.0%

diethyl (2-bromoallyl)-(2'-bromobutenyl)malonate (115819-26-6) → diethyl 3,4-bis(methylene)cyclohexane-1,1-dicarboxylate (94922-20-0)

Guidance literature:

With indium; palladium 10% on activated carbon; lithium chloride; In N,N-dimethyl-formamide; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1002/bkcs.10106

Reference yield: 10.0%

2-(2-Bromo-allyl)-2-but-3-ynyl-malonic acid diethyl ester (119952-30-6) → diethyl 3,4-bis(methylene)cyclohexane-1,1-dicarboxylate (94922-20-0)

Guidance literature:

With piperidine; formic acid; triphenylphosphine; palladium diacetate; In acetonitrile; at 80 ℃;

DOI:10.1016/S0040-4039(00)80488-8

upstream raw materials:

diethyl 7-octen-2-yne-5,5-dicarboxylate

2-(2-Bromo-allyl)-2-but-3-ynyl-malonic acid diethyl ester

2-bromo-4,4-di(ethoxycarbonyl)octa-1,7-diene

diethyl (2-bromoallyl)-(2'-bromobutenyl)malonate