5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL

Base Information

• Chemical Name: 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL
• CAS No.: 26028-63-7
• Molecular Formula: C10H10 Cl N3 S
• Molecular Weight: 239.728
• Hs Code.: 2933990090
• Mol file: 26028-63-7.mol

Synonyms:4H-1,2,4-Triazole-3-thiol,5-(m-chlorophenyl)-4-ethyl- (8CI)

Chemical Property of 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL

Chemical Property:

• Vapor Pressure: 0.000249mmHg at 25°C
• Boiling Point: 324.2°Cat760mmHg
• Flash Point: 149.9°C
• PSA: 69.51000
• Density: 1.37g/cm³
• LogP: 2.90710

Purity/Quality:

98%min ^*data from raw suppliers

5-(3-Chlorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL

There total 3 articles about 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(3-chlorobenzoyl)-4-ethylthiosemicarbazide (26036-05-5) → C10H10ClN3S (26028-63-7)

Guidance literature:

With sodium hydroxide; for 2h; Reflux;

DOI:10.1016/j.ejmech.2012.11.026

Reference yield:

3-chlorobenzhydrazide (1673-47-8) → C10H10ClN3S (26028-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.08 h / Reflux

2: sodium hydroxide / Reflux

With sodium hydroxide; In ethanol;

DOI:10.1016/j.ejmech.2012.11.040

Reference yield:

→ 5-(3-chloro-phenyl)-4-ethyl-2,4-dihydro-[1,2,4]triazole-3-thione (26028-63-7)

Guidance literature:

entspr. Thiosemicarbazid, NaOH;

DOI:10.1002/jps.2600581123

upstream raw materials:

3-chlorobenzhydrazide

1-(3-chlorobenzoyl)-4-ethylthiosemicarbazide

Downstream raw materials:

7-[4-{[3-(3-Chlorophenyl)-4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Refernces

• 1、 Plech, Tomasz,Luszczki, Jarogniew J.,Wujec, Monika,Flieger, Jolanta,Pizon, Magdalena. "Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles". . p. 208 - 215. Retrieved 2013/04/23.