24-Homo-1,25-dihydroxyvitamin D3

Base Information

Chemical Name:24-Homo-1,25-dihydroxyvitamin D3
CAS No.:103656-40-2
Molecular Formula:C28H46 O3
Molecular Weight:430.66
Hs Code.:
UNII:F35KTH803S
Wikidata:Q27277567
Metabolomics Workbench ID:35912
Mol file:103656-40-2.mol

Synonyms:24-homo-1,25-dihydroxyvitamin D3;24-homo-calcitriol

Suppliers and Price of 24-Homo-1,25-dihydroxyvitamin D3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
24-HomoCalcitriol
1mg
$ 1420.00

Crysdot
CalcitriolImpuritiesD 98+%
10mg
$ 3125.00

Crysdot
CalcitriolImpuritiesD 98+%
5mg
$ 1945.00

ChemScene
CalcitriolImpuritiesD 95.18%
10mg
$ 5400.00

ChemScene
CalcitriolImpuritiesD 95.18%
5mg
$ 3360.00

ChemScene
CalcitriolImpuritiesD 95.18%
1mg
$ 1080.00

Total 28 raw suppliers

Chemical Property of 24-Homo-1,25-dihydroxyvitamin D3

Chemical Property:

Vapor Pressure:1.2E-15mmHg at 25°C
Boiling Point:575.6°Cat760mmHg
PKA:14.43±0.40(Predicted)
Flash Point:240.5°C
PSA：60.69000
Density:1.05g/cm³
LogP:6.09480
XLogP3:5.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:430.34469533
Heavy Atom Count:31
Complexity:703

Purity/Quality:

99% ^*data from raw suppliers

24-HomoCalcitriol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CCCCC(C)(C)O)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
Isomeric SMILES:C[C@H](CCCCC(C)(C)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](C[C@@H](C3=C)O)O)C
Uses A Calcitriol (C144500) analog with potent effects on cell growth regulation and immune responses

Technology Process of 24-Homo-1,25-dihydroxyvitamin D3

There total 10 articles about 24-Homo-1,25-dihydroxyvitamin D3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-{(1S,5R)-5-(tert-Butyl-dimethyl-silanyloxy)-3-[2-[(1R,3aS,7aR)-1-((R)-1,6-dimethyl-6-trimethylsilanyloxy-heptyl)-7a-methyl-octahydro-inden-(4E)-ylidene]-eth-(Z)-ylidene]-2-methylene-cyclohexyloxy}-tetrahydro-pyran

: 103656-40-2
24-homo-1,25-dihydroxyvitamin D₃

Guidance literature:: With camphor-10-sulfonic acid; In methanol; water; at 30 ℃; for 6h;
DOI:10.1021/ja003976k

Reference yield:

: 103656-34-4
(22E)-24-homocholesta-5,22-diene-1α,3β,25-triol

: 103656-40-2
24-homo-1,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / pyridine / 16 h / Ambient temperature

2: 92 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / Ambient temperature

3: N-bromosuccinimide, tetra-n-butylammonium bromide, tetra-n-butylammonium fluoride

4: 1.) benzene, ethanol, irradiation, 0 deg C, 5 min; 2.) reflux, 1 h

5: 5percent KOH / methanol; tetrahydrofuran / 20 h / Ambient temperature

With potassium hydroxide; N-Bromosuccinimide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethyl acetate;
DOI:10.1248/cpb.34.4508

Reference yield:

: 99741-49-8
1α,3β-bis(methoxymethoxy)chola-5,23-dien-22-ol

: 103656-40-2
24-homo-1,25-dihydroxyvitamin D₃

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / xylene / 2 h / Heating

2: 93 percent / tetrahydrofuran / 1 h / Ambient temperature

3: 95 percent / 6 M HCl / tetrahydrofuran / 2.5 h / 50 °C

4: 77 percent / pyridine / 16 h / Ambient temperature

5: 92 percent / hydrogen / 10percent Pd-C / ethyl acetate / 3 h / Ambient temperature

6: N-bromosuccinimide, tetra-n-butylammonium bromide, tetra-n-butylammonium fluoride

7: 1.) benzene, ethanol, irradiation, 0 deg C, 5 min; 2.) reflux, 1 h

8: 5percent KOH / methanol; tetrahydrofuran / 20 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; N-Bromosuccinimide; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethyl acetate; xylene;
DOI:10.1248/cpb.34.4508