Technology Process of Piperidine, 1-[[(1,1-dimethylethyl)imino]methyl]-2-(phenylseleno)-
There total 1 articles about Piperidine, 1-[[(1,1-dimethylethyl)imino]methyl]-2-(phenylseleno)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 93 percent / (NH4)2SO4 / toluene / Heating
2: 1.) t-BuLi / 1.) THF, -20 deg C, 1 h; 2.) THF, -78 -> 0 deg C, 3 h
With
ammonium sulfate; tert.-butyl lithium;
In
toluene;
DOI:10.1021/ja00323a035
- Guidance literature:
-
Multi-step reaction with 4 steps
1: KHCO3, Na2SO4 / 24 h
2: 1.) n-BuLi / 1.) ether, THF, from -78 deg C to -20 deg C, 1 h, 2.) from -78 deg C to 0 deg C
3: 95 percent / hydrazine, acetic acid / aq. ethanol / 3 h / 25 °C
4: 77 percent / LiAlH4 / diethyl ether / 3 h / Ambient temperature
With
lithium aluminium tetrahydride; n-butyllithium; potassium hydrogencarbonate; acetic acid; sodium sulfate; hydrazine;
In
diethyl ether; ethanol;
DOI:10.1021/jo00207a023
- Guidance literature:
-
Multi-step reaction with 5 steps
1: KHCO3, Na2SO4 / 24 h
2: 1.) n-BuLi / 1.) ether, THF, from -78 deg C to -20 deg C, 1 h, 2.) from -78 deg C to 0 deg C
3: 1a.) t-BuLi, 1b.) TMEDA / 1a.) THF, from -78 deg C to -20 deg C, 1.5 h, 1b.) 0.5 h, 2.) from -78 deg C to 0 deg C, 4 h
4: 95 percent / hydrazine, acetic acid / aq. ethanol / 3 h / 25 °C
5: 90 percent / DIBAL
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; diisobutylaluminium hydride; potassium hydrogencarbonate; acetic acid; sodium sulfate; hydrazine;
In
ethanol;
DOI:10.1021/jo00207a023
