Benzoic acid, 4-(2-amino-1,6,8,9-tetrahydro-4-oxopyrimido[4,5-b][1,6]naphthyridin-7( 4H)-yl)-

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Chemical Name:Benzoic acid, 4-(2-amino-1,6,8,9-tetrahydro-4-oxopyrimido[4,5-b][1,6]naphthyridin-7( 4H)-yl)-
CAS No.:95044-85-2
Molecular Formula:C17H15N5O3
Molecular Weight:337.338
Hs Code.:

Synonyms:

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Chemical Property of Benzoic acid, 4-(2-amino-1,6,8,9-tetrahydro-4-oxopyrimido[4,5-b][1,6]naphthyridin-7( 4H)-yl)-

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Technology Process of Benzoic acid, 4-(2-amino-1,6,8,9-tetrahydro-4-oxopyrimido[4,5-b][1,6]naphthyridin-7( 4H)-yl)-

There total 9 articles about Benzoic acid, 4-(2-amino-1,6,8,9-tetrahydro-4-oxopyrimido[4,5-b][1,6]naphthyridin-7( 4H)-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 95017-78-0
2,4-diamino-7-(4-carboxyphenyl)-5-deaza-6,7,8,9-tetrahydropyrido<3,4-g>pteridine

: 95044-85-2
4-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-1,3,6,9-tetraaza-anthracen-6-yl)-benzoic acid

Guidance literature:: With sodium hydroxide; for 4h; Heating;
DOI:10.1021/jo00207a020

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 95044-85-2
4-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-1,3,6,9-tetraaza-anthracen-6-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / K₂CO₃ / dimethylsulfoxide / 7 h / 120 °C

2: 83 percent / dicyclohexylcarbodiimide, pyridine, trifluoroacetic acid / dimethylsulfoxide; benzene / 5 °C

3: 96 percent / magnesium sulfate / tetrahydrofuran / 2 h / Ambient temperature

4: Et₃N / tetrahydrofuran / 1.) -30 deg C, 20 min, 2.) RT, 1 h

5: NH₃ / methanol / Ambient temperature

6: 1.) KOt-Bu / 1.) DMF, RT, 1 h, 2.) 100 deg C, 5 h

7: 88 percent / 88percent formic acid / 72 h / Ambient temperature

8: 86 percent / 1 N NaOH / 4 h / Heating

With pyridine; sodium hydroxide; formic acid; potassium tert-butylate; ammonia; magnesium sulfate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00207a020

Reference yield:

: 58656-98-7
tert-butyl 4-fluorobenzoate

: 95044-85-2
4-(2-Amino-4-oxo-3,5,7,8-tetrahydro-4H-1,3,6,9-tetraaza-anthracen-6-yl)-benzoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 73 percent / K₂CO₃ / dimethylsulfoxide / 7 h / 120 °C

2: 83 percent / dicyclohexylcarbodiimide, pyridine, trifluoroacetic acid / dimethylsulfoxide; benzene / 5 °C

3: 96 percent / magnesium sulfate / tetrahydrofuran / 2 h / Ambient temperature

4: Et₃N / tetrahydrofuran / 1.) -30 deg C, 20 min, 2.) RT, 1 h

5: NH₃ / methanol / Ambient temperature

6: 1.) KOt-Bu / 1.) DMF, RT, 1 h, 2.) 100 deg C, 5 h

7: 88 percent / 88percent formic acid / 72 h / Ambient temperature

8: 86 percent / 1 N NaOH / 4 h / Heating

With pyridine; sodium hydroxide; formic acid; potassium tert-butylate; ammonia; magnesium sulfate; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dimethyl sulfoxide; benzene;
DOI:10.1021/jo00207a020