2,5-Diethoxy-2-(diethoxymethyl)tetrahydrofuran

Base Information

• Chemical Name: 2,5-Diethoxy-2-(diethoxymethyl)tetrahydrofuran
• CAS No.: 60664-55-3
• Molecular Formula: C13H26O5
• Molecular Weight: 262.346
• Hs Code.: 2932190090
• DSSTox Substance ID: DTXSID80976097
• Nikkaji Number: J69.817B
• Mol file: 60664-55-3.mol

Synonyms:2,5-Diethoxy-2-(diethoxymethyl)tetrahydrofuran;60664-55-3;Tetrahydro-2,5-diethoxy-2-(diethoxymethyl)furan;FURAN, TETRAHYDRO-2,5-DIETHOXY-2-(DIETHOXYMETHYL)-;2-(diethoxymethyl)-2,5-diethoxyoxolane;DTXSID80976097;2,5-Diethoxy-2-(diethoxymethyl)oxolane;LS-70593

Chemical Property of 2,5-Diethoxy-2-(diethoxymethyl)tetrahydrofuran

Chemical Property:

• Vapor Pressure: 0.000456mmHg at 25°C
• Boiling Point: 324.7°C at 760 mmHg
• Flash Point: 124.5°C
• PSA: 46.15000
• Density: 1.01g/cm³
• LogP: 2.29130
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 262.17802393
• Heavy Atom Count: 18
• Complexity: 217

Purity/Quality:

99%min ^*data from raw suppliers

2,5-DIETHOXY-2-(DIETHOXYMETHYL)TETRAHYDROFURAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1CCC(O1)(C(OCC)OCC)OCC

Technology Process of 2,5-Diethoxy-2-(diethoxymethyl)tetrahydrofuran

There total 8 articles about 2,5-Diethoxy-2-(diethoxymethyl)tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,5-Diethoxy-2-diethoxymethyl-2,5-dihydrofuran (100538-74-7) → 2,5-diethoxy-2-diethoxymethyltetrahydrofuran (60664-55-3)

Guidance literature:

With hydrogen; nickel; In ethanol; for 2h; Ambient temperature;

DOI:10.1007/BF00762049

Reference yield:

furfural (98-01-1) → 2,5-diethoxy-2-diethoxymethyltetrahydrofuran (60664-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: bromine

2: Raney nickel; ethanol / 88260.9 Torr / Hydrogenation

With ethanol; bromine; nickel;

DOI:10.1021/ja01158a058

Reference yield:

2-(furan-2-yl)-1,3-dioxolane (1708-41-4) → 2,5-diethoxy-2-diethoxymethyltetrahydrofuran (60664-55-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 61.6 percent / NH₄Br / 3.6 h / -15 °C / electrolysis (current of 1.5 A at ca. 30 V)

2: 87 percent / H₂ / Raney nickel / ethanol / 2 h / Ambient temperature

With hydrogen; ammonium bromide; nickel; In ethanol;

DOI:10.1007/BF00762049

upstream raw materials:

2,5-Diethoxy-2-diethoxymethyl-2,5-dihydrofuran

2-(furan-2-yl)-1,3-dioxolane

furfural

Downstream raw materials:

3,8-dihydroxy-2-methyl-4H-chromen-4-one

succinic acid

3,4-dihydropyrrolo[1,2-a]-pyrazine

Refernces