2,2-Dichloro-1-(2-hydroxy-4-methoxyphenyl)ethanone

Base Information

• Chemical Name: 2,2-Dichloro-1-(2-hydroxy-4-methoxyphenyl)ethanone
• CAS No.: 95235-25-9
• Molecular Formula: C₉H₈Cl₂O₃
• Molecular Weight: 235.067
• DSSTox Substance ID: DTXSID90552669

Synonyms:95235-25-9;2,2-dichloro-1-(2-hydroxy-4-methoxyphenyl)ethanone;DTXSID90552669;2,2-Dichloro-1-(2-hydroxy-4-methoxyphenyl)ethan-1-one

Chemical Property of 2,2-Dichloro-1-(2-hydroxy-4-methoxyphenyl)ethanone

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 233.9850495
• Heavy Atom Count: 14
• Complexity: 208

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)C(=O)C(Cl)Cl)O

Technology Process of 2,2-Dichloro-1-(2-hydroxy-4-methoxyphenyl)ethanone

There total 4 articles about 2,2-Dichloro-1-(2-hydroxy-4-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

dichloroacethyl chloride (79-36-7) + 1,3-Dimethoxybenzene (151-10-0) → 2-hydroxy-4-methoxy-ω,ω-dichloroacetophenone (95235-25-9) + 2,4-dimethoxy-ω,ω-dichloroacetophenone (116045-95-5)

Guidance literature:

aluminium trichloride; at 0 - 10 ℃; for 24h; Product distribution; different temperature; varying amounts of substrates;

DOI:10.1016/S0040-4020(01)90320-5

Reference yield: 5.0%

dichloroacethyl chloride (79-36-7) + 1,3-Dimethoxybenzene (151-10-0) → 2-hydroxy-4-methoxy-ω,ω-dichloroacetophenone (95235-25-9) + 1,1-dichloro-2,2-bis(2,4-dimethoxyphenyl)ethene (116045-96-6) + 1,1,4,4-tetrachloro-2,2,3-tris(2',4'-dimethoxyphenyl)butane (116045-99-9)

Guidance literature:

aluminium trichloride; at 0 - 10 ℃; for 24h;

DOI:10.1016/S0040-4020(01)90320-5

Reference yield:

3-methoxyphenyl 2,2-dichloroacetate → 2-hydroxy-4-methoxy-ω,ω-dichloroacetophenone (95235-25-9)

Guidance literature:

With aluminium trichloride; at 120 ℃;

upstream raw materials:

dichloroacethyl chloride

1,3-Dimethoxybenzene

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