tert-butyl 3-hydroxy-4H,5H,6H,7H-[1,2]oxazolo[4,5- c]pyridine-5-carboxylate

Base Information

Chemical Name:tert-butyl 3-hydroxy-4H,5H,6H,7H-[1,2]oxazolo[4,5- c]pyridine-5-carboxylate
CAS No.:95579-09-2
Molecular Formula:C₁₁H₁₆N₂O₄
Molecular Weight:240.259
Hs Code.:
Mol file:95579-09-2.mol

Synonyms:tert-butyl 3-hydroxy-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-5-carboxylate;tert.Butyl 3-hydroxy-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-5-carboxylate;3-Hydroxy-6,7-dihydro-4H-isoxazolo[4,5-c]pyridine-5-carboxylic acid tert-butyl ester;

Suppliers and Price of tert-butyl 3-hydroxy-4H,5H,6H,7H-[1,2]oxazolo[4,5- c]pyridine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 4 raw suppliers

Chemical Property of tert-butyl 3-hydroxy-4H,5H,6H,7H-[1,2]oxazolo[4,5- c]pyridine-5-carboxylate

Chemical Property:

Melting Point:151 - 152 °C (light petroleum)
PSA：75.80000
LogP:1.61130

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 3-hydroxy-4H,5H,6H,7H-[1,2]oxazolo[4,5- c]pyridine-5-carboxylate

There total 3 articles about tert-butyl 3-hydroxy-4H,5H,6H,7H-[1,2]oxazolo[4,5- c]pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

toluene-light petroleum: toluene-light petroleum

: 24424-99-5
di-tert-butyl dicarbonate

: 95579-09-2
tert-butyl 3-hydroxy-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-5-carboxylate

Guidance literature:: With potassium carbonate; In water; ethyl acetate;

Reference yield: 57.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 53601-99-3
4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridin-3-one; hydrobromide

: 95579-09-2
tert-butyl 3-hydroxy-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-5-carboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; water; for 20h; Ambient temperature;
DOI:10.1021/jm00156a018

Reference yield:

: 53601-98-2
methyl 3-hydroxy-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-5-carboxylate

: 95579-09-2
tert-butyl 3-hydroxy-4,5,6,7-tetrahydroisoxazolo<4,5-c>pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 33percent HBr, acetic acid / 168 h / Ambient temperature

2: 57 percent / K₂CO₃ / H₂O; tetrahydrofuran / 20 h / Ambient temperature

With hydrogen bromide; potassium carbonate; acetic acid; In tetrahydrofuran; water;
DOI:10.1021/jm00156a018