(E)-1-(3-methoxythiophen-2-yl)-3-phenylprop-2-en-1-one

Base Information

• Chemical Name: (E)-1-(3-methoxythiophen-2-yl)-3-phenylprop-2-en-1-one
• CAS No.: 95602-72-5
• Molecular Formula: C14H12O2S
• Molecular Weight: 244.314
• DSSTox Substance ID: DTXSID301204525
• Mol file: 95602-72-5.mol

Synonyms:(E)-1-(3-methoxythiophen-2-yl)-3-phenylprop-2-en-1-one;DTXSID301204525;AKOS000281502;95602-72-5;(2E)-1-(3-methoxy-2-thienyl)-3-phenyl-2-propen-1-one;2-Propen-1-one, 1-(3-methoxy-2-thienyl)-3-phenyl-, (E)-

Chemical Property of (E)-1-(3-methoxythiophen-2-yl)-3-phenylprop-2-en-1-one

Chemical Property:

• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 244.05580079
• Heavy Atom Count: 17
• Complexity: 282

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(SC=C1)C(=O)C=CC2=CC=CC=C2
• Isomeric SMILES: COC1=C(SC=C1)C(=O)/C=C/C2=CC=CC=C2

Technology Process of (E)-1-(3-methoxythiophen-2-yl)-3-phenylprop-2-en-1-one

There total 1 articles about (E)-1-(3-methoxythiophen-2-yl)-3-phenylprop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-methoxy-thiophene (17573-92-1) + cinnamoyl chloride (102-92-1,17082-09-6) → (E)-1-(3-methoxythiophen-2-yl)-3-phenyl-2-propen-1-one (95602-72-5)

Guidance literature:

With tin(IV) chloride; In dichloromethane; for 0.75h; Cooling;

DOI:10.1039/c9nj04612g

Reference yield: 81.0%

nitromethane (75-52-5) + (E)-1-(3-methoxythiophen-2-yl)-3-phenyl-2-propen-1-one (95602-72-5) → 1-(3-methoxythiophen-2-yl)-4-nitro-3-phenylbutan-1-one

Guidance literature:

With potassium hydroxide; In ethanol; at 60 ℃;

DOI:10.1039/c9nj04612g

Reference yield: 71.0%

(E)-1-(3-methoxythiophen-2-yl)-3-phenyl-2-propen-1-one (95602-72-5) → E-1-(3-Hydroxy-2-thienyl)-3-phenyl-2-propen-1-on (95602-77-0)

Guidance literature:

With boron tribromide; In dichloromethane; at 5 ℃; for 0.5h;

DOI:10.1002/ardp.19853180111

upstream raw materials:

3-methoxy-thiophene

cinnamoyl chloride

Downstream raw materials:

E-1-(3-Hydroxy-2-thienyl)-3-phenyl-2-propen-1-on