Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-

Base Information

• Chemical Name: Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-
• CAS No.: 60230-74-2
• Molecular Formula: C17H14N2O
• Molecular Weight: 262.3059
• DSSTox Substance ID: DTXSID50208978
• Wikidata: Q83083124
• Mol file: 60230-74-2.mol

Synonyms:BRN 0665978;60230-74-2;Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-;3-(4,5-Dihydropyrazolo(1,5-a)quinolin-2-yl)phenol;3-(4,5-dihydropyrazolo[1,5-a]quinolin-2-yl)phenol;4,5-Dihydro-2-(3-hydroxyphenyl)pyrazolo(1,5-a)quinoline;DTXSID50208978;ZXHJOSWIKUPFDB-UHFFFAOYSA-N;LS-104406;2-(3-Hydroxyphenyl)-4,5-dihydro-pyrazolo[1,5-a]quinoline

Chemical Property of Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-

Chemical Property:

• Boiling Point: 494.3°Cat760mmHg
• Flash Point: 252.7°C
• Density: 1.27g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 262.110613074
• Heavy Atom Count: 20
• Complexity: 348

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CC2=CC(=NN2C3=CC=CC=C31)C4=CC(=CC=C4)O

Technology Process of Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)-

There total 10 articles about Phenol, 3-(4,5-dihydropyrazolo(1,5-a)quinolin-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(m-Benzyloxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinoline (60230-71-9) → 4,5-dihydro-2(3-hydroxyphenyl)pyrazolo<1,5-a>quinoline (60230-74-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 6h; Ambient temperature;

Reference yield:

1-amino-3,4-dihydroquinoline-2(1H)-one (60230-78-6) → 4,5-dihydro-2(3-hydroxyphenyl)pyrazolo<1,5-a>quinoline (60230-74-2)

Guidance literature:

Multi-step reaction with 5 steps

1: p.toluenesulfonic acid / benzene / Heating

2: Na / various solvent(s) / Heating

3: 98 percent / NaOH / ethanol / Heating

4: 85 percent / neat (no solvent) / Heating

5: 90 percent / H₂ / Pd/C / methanol / 6 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethanol; benzene;

Reference yield:

ethyl 3-(3-benzyloxyphenyl)-3-oxopropanoate (73083-19-9) → 4,5-dihydro-2(3-hydroxyphenyl)pyrazolo<1,5-a>quinoline (60230-74-2)

Guidance literature:

Multi-step reaction with 5 steps

1: p.toluenesulfonic acid / benzene / Heating

2: Na / various solvent(s) / Heating

3: 98 percent / NaOH / ethanol / Heating

4: 85 percent / neat (no solvent) / Heating

5: 90 percent / H₂ / Pd/C / methanol / 6 h / Ambient temperature

With sodium hydroxide; hydrogen; sodium; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethanol; benzene;

upstream raw materials:

2-(m-Benzyloxyphenyl)-4,5-dihydropyrazolo[1,5-a]quinoline

1-amino-3,4-dihydroquinoline-2(1H)-one

ethyl 3-(3-benzyloxyphenyl)-3-oxopropanoate

sodium 3-(2-aminophenyl)propionate

Downstream raw materials:

4,5-dihydro-2(3-n.propyloxyphenyl)pyrazolo<1,5-a>quinoline

4,5-dihydro-2(3-ethoxyphenyl)pyrazolo<1,5-a>quinoline