t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester

Base Information

Chemical Name:t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester
CAS No.:99593-01-8
Molecular Formula:C68H118 N10 O13
Molecular Weight:0
Hs Code.:
Mol file:99593-01-8.mol

Synonyms:t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester

Suppliers and Price of t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 4 raw suppliers

Chemical Property of t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester

Chemical Property:

PSA：326.53000
LogP:11.08410

Purity/Quality:: HPLC>98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester

There total 9 articles about t-butoxycarbonylleucyl-leucyl-leucyl-leucyl-aminoisobutyryl-leucyl-leucyl-leucyl-leucyl-aminoisobutyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 103527-62-4
H-Leu-Leu-Leu-Leu-Aib-OBzl

: 99593-08-5
Boc-Leu-Leu-Leu-Leu-Aib-OH

: 99593-01-8
Boc-Leu-Leu-Leu-Leu-Aib-Leu-Leu-Leu-Leu-Aib-OBzl

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; 1.) 0 deg C, 3 h, 2.) room temperature, overnight;;
DOI:10.1246/bcsj.58.1473

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 99593-01-8
Boc-Leu-Leu-Leu-Leu-Aib-Leu-Leu-Leu-Leu-Aib-OBzl

Guidance literature:: Multi-step reaction with 9 steps

1: dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

2: 3M HCl / ethyl acetate / 1.5 h / 0 °C

3: dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

4: 3M HCl / ethyl acetate / 1.5 h / 0 °C

5: 92 percent / dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

6: 3M HCl / ethyl acetate / 1.5 h / 0 °C

7: 94 percent / dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

8: 3M HCl / ethyl acetate / 1.5 h / 0 °C

9: 74 percent / dicyclhexylcarbodiimide, N-methylmorpholine, 1-hydroxy-1H-bezotriazole; / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1246/bcsj.58.1473

Reference yield:

: 79118-23-3
Boc-Leu-Aib-OBzl

: 99593-01-8
Boc-Leu-Leu-Leu-Leu-Aib-Leu-Leu-Leu-Leu-Aib-OBzl

Guidance literature:: Multi-step reaction with 8 steps

1: 3M HCl / ethyl acetate / 1.5 h / 0 °C

2: dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

3: 3M HCl / ethyl acetate / 1.5 h / 0 °C

4: 92 percent / dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

5: 3M HCl / ethyl acetate / 1.5 h / 0 °C

6: 94 percent / dicyclhexylcarbodiimide, N-methylmorpholine / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

7: 3M HCl / ethyl acetate / 1.5 h / 0 °C

8: 74 percent / dicyclhexylcarbodiimide, N-methylmorpholine, 1-hydroxy-1H-bezotriazole; / CH₂Cl₂ / 1.) 0 deg C, 3 h, 2.) room temperature, overnight;

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate;
DOI:10.1246/bcsj.58.1473