Chemical Property of ent-Kaur-16-en-19-oic acid
Chemical Property:
- Vapor Pressure:1.79E-08mmHg at 25°C
- Melting Point:171-172 °C
- Boiling Point:426.6°C at 760 mmHg
- PKA:4.70±0.40(Predicted)
- Flash Point:202.8°C
- PSA：37.30000
- Density:1.1g/cm3
- LogP:5.04010
- Storage Temp.:?20°C
- XLogP3:5.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:1
- Exact Mass:302.224580195
- Heavy Atom Count:22
- Complexity:538
- Purity/Quality:
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99%, *data from raw suppliers
ent-KaurenoicAcid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC12CCCC(C1CCC34C2CCC(C3)C(=C)C4)(C)C(=O)O
- Isomeric SMILES:C[C@@]12CCC[C@@]([C@H]1CC[C@]34[C@H]2CC[C@@H](C3)C(=C)C4)(C)C(=O)O
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Description
Kaurenoic acid is a diterpene that has been found in C. langsdorffii and has diverse biological activities, including anticancer, antibacterial, antioxidant, and anti-inflammatory properties. It is cytotoxic to 22Rv1 and LNCaP prostate, HT-29, HCT116, SW480, and SW620 colon, and MCF-7 breast cancer cells with IC50 values ranging from 15.03 to 48.87 μg/ml. Kaurenoic acid is active against S. epidermidis, S. capitis, E. faecalis, and S. haemolyticus in vitro (MICs = 6.25-12.5 μg/ml). Kaurenoic acid (50 and 100 mg/kg) reduces colonic myeloperoxidase (MPO) activity and malondialdehyde (MDA) levels in a rat model of acetic acid-induced colitis, as well as colonic tissue damage, leukocytic infiltration, and submucosal edema when administered at a dose of 100 mg/kg.
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Uses
ent-Kaurenoic Acid can be used in biological study. Kinetic profile of guaco syrup metabolites like coumarin, 7-hydroxycoumarin, o-coumaric acid, kaurenoic acid can be performed for identification of alternative route of coumarin metabolism in human plasma.
