2-(4-Chlorophenyl)-3H-imidazo(4,5-b)pyridine-3-acetamide

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-3H-imidazo(4,5-b)pyridine-3-acetamide
• CAS No.: 118695-83-3
• Molecular Formula: C14H11 Cl N4 O
• Molecular Weight: 286.7163
• DSSTox Substance ID: DTXSID00152210
• Nikkaji Number: J460.430J
• Wikidata: Q83018823
• ChEMBL ID: CHEMBL103699
• Mol file: 118695-83-3.mol

Synonyms:2-(4-chlorophenyl)-3H-imidazo(4,5-b)pyridine-3-acetamide;2-(4-chlorophenyl)-3H-imidazo-(4,5b)pyridine-3-acetamide;AHR 12245;AHR-12245;CPIPA

Chemical Property of 2-(4-Chlorophenyl)-3H-imidazo(4,5-b)pyridine-3-acetamide

Chemical Property:

• Vapor Pressure: 2.42E-12mmHg at 25°C
• Boiling Point: 554.6°Cat760mmHg
• Flash Point: 289.2°C
• Density: 1.46g/cm³
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 286.0621387
• Heavy Atom Count: 20
• Complexity: 359

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)N(C(=N2)C3=CC=C(C=C3)Cl)CC(=O)N

Technology Process of 2-(4-Chlorophenyl)-3H-imidazo(4,5-b)pyridine-3-acetamide

There total 5 articles about 2-(4-Chlorophenyl)-3H-imidazo(4,5-b)pyridine-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N-<2-<(2-amino-2-oxoethyl)amino>-3-pyridyl>-4-chlorobenzamide (118699-09-5) → 2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine-3-acetamide (118695-83-3)

Guidance literature:

at 200 ℃; for 0.116667h;

DOI:10.1021/jm00114a007

Reference yield:

2-Chloro-3-nitropyridine (5470-18-8,34515-82-7) → 2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine-3-acetamide (118695-83-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 73 percent / Et₃N / acetonitrile / 16.5 h / Heating

2: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

3: Et₃N / acetone / Ambient temperature

4: 53 percent / 0.12 h / 200 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetone; acetonitrile;

DOI:10.1021/jm00114a007

Reference yield:

2-<(3-nitro-2-pyridinyl)amino>acetamide (118699-03-9) → 2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine-3-acetamide (118695-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / 5percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

2: Et₃N / acetone / Ambient temperature

3: 53 percent / 0.12 h / 200 °C

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; acetone;

DOI:10.1021/jm00114a007

upstream raw materials:

N-<2-<(2-amino-2-oxoethyl)amino>-3-pyridyl>-4-chlorobenzamide

2-(4-chlorophenyl)-3H-imidazo<4,5-b>pyridine

Chloroacetamide

2-Chloro-3-nitropyridine

Downstream raw materials:

2-(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetamide-4-oxide