Technology Process of 2-(4-(2-Nitro-1-(4-methoxyphenyl)-2-phenylvinyl)phenoxy)-N-ethylpyrrolidin-2-one
There total 4 articles about 2-(4-(2-Nitro-1-(4-methoxyphenyl)-2-phenylvinyl)phenoxy)-N-ethylpyrrolidin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
nitric acid; acetic acid;
for 2h;
Ambient temperature;
DOI:10.1021/jm00366a008
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) magnesium, iodine / 1.) ether, reflux, 2 h, 2.) ether, THF, reflux, 5 h
2: 51 percent / KOH, tetrabutylammonium hydrogen sulfate / tetrahydrofuran / 1.) RT, 30 min, 2.) 40 - 50 deg C, 5 h
3: 81 percent / glacial acetic acid, nitric acid / 2 h / Ambient temperature
With
potassium hydroxide; iodine; nitric acid; tetra(n-butyl)ammonium hydrogensulfate; magnesium; acetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm00366a008
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) magnesium, iodine / 1.) ether, reflux, 2 h, 2.) ether, THF, reflux, 5 h
2: 51 percent / KOH, tetrabutylammonium hydrogen sulfate / tetrahydrofuran / 1.) RT, 30 min, 2.) 40 - 50 deg C, 5 h
3: 81 percent / glacial acetic acid, nitric acid / 2 h / Ambient temperature
With
potassium hydroxide; iodine; nitric acid; tetra(n-butyl)ammonium hydrogensulfate; magnesium; acetic acid;
In
tetrahydrofuran;
DOI:10.1021/jm00366a008