8-Quinolinamine, 4-methyl-

Base Information

• Chemical Name: 8-Quinolinamine, 4-methyl-
• CAS No.: 62748-01-0
• Molecular Formula: C10H10N2
• Molecular Weight: 158.203
• Hs Code.: 2933499090
• NSC Number: 118960
• DSSTox Substance ID: DTXSID4069632
• Nikkaji Number: J90.211J
• Wikidata: Q81996580
• ChEMBL ID: CHEMBL1890904
• Mol file: 62748-01-0.mol

Synonyms:4-methylquinolin-8-amine;62748-01-0;8-Amino-4-methylquinoline;8-Quinolinamine, 4-methyl-;8-Aminolepidine;4-Methyl-8-aminoquinoline;4-Methyl-8-quinolinamine;NSC118960;8-Amino-4-methylqunoline;4-Methyl-8-quinolinamine #;SCHEMBL4640797;CHEMBL1890904;DTXSID4069632;MFCD03819702;AKOS000268625;NSC 118960;NSC-118960;PS-4002;NCGC00188240-01;4-methyl-quinolin-8-ylamine, AldrichCPR;CS-0152931;FT-0737129;A18996;EN300-1616790;J-515821

Chemical Property of 8-Quinolinamine, 4-methyl-

Chemical Property:

• Vapor Pressure: 0.000128mmHg at 25°C
• Melting Point: 84 °C
• Refractive Index: 1.681
• Boiling Point: 334.4 °C at 760 mmHg
• PKA: 4.74±0.13(Predicted)
• Flash Point: 182.5 °C
• PSA: 38.91000
• Density: 1.169 g/cm³
• LogP: 2.70660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 158.084398327
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

98%min ^*data from raw suppliers

8-Amino-4-methylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C=CC=C(C2=NC=C1)N

Technology Process of 8-Quinolinamine, 4-methyl-

There total 17 articles about 8-Quinolinamine, 4-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-methyl-8-nitroquinoline (2801-29-8) → 4-methyl-8-aminoquinoline (62748-01-0)

Guidance literature:

With sodium tetrahydroborate; palladium on activated charcoal; In methanol; for 0.5h;

DOI:10.1080/00397919908085754

Reference yield: 96.0%

4-methylquinolin-8-ol (3846-73-9) → 4-methyl-8-aminoquinoline (62748-01-0)

Guidance literature:

With ammonium sulfate; ammonium hydroxide; at 170 ℃; for 48h;

DOI:10.1016/0040-4020(95)01118-8

Reference yield:

4-chlorocarbonyl-8-nitroquinoline → 4-methyl-8-aminoquinoline (62748-01-0)

Guidance literature:

4-chlorocarbonyl-8-nitroquinoline; With hydrogenchloride; In water; at 65 ℃; for 0.416667h;

With zinc; In water; at 75 ℃; for 2h; Temperature;

upstream raw materials:

4-methyl-8-nitroquinoline

(4-methyl-8-nitro-[2]quinolyl)-hydrazine

4-methylquinolin-8-ol

2-nitro-aniline

Downstream raw materials:

((C₁₂H₆N₂C₆H₄OCH₃)CH₂CH₂)2C₆H₄

2,4,6-Trimethyl-benzenesulfonate1-amino-8-formylamino-4-methyl-quinolinium;

C₆H₄(C₂H₄C₁₂H₆N₂C₆H₄Br)2

4-methyl-7-anisyl-1,10-phenanthroline

Refernces

• 1、 Lutun, Stephane,Guichard, Eric,Hasiak, Bruno,Couturier, Daniel. "Efficient synthesis of 4-methyl-1,10-phenanthroline starting from 8- aminolepidine". . p. 175 - 180. Retrieved 1999.
• 2、 -. "Synthetic method of 2, 9-dinitro-4, 7-dimethyl-1, 10-phenanthroline". Paragraph 0005; 0007. . Retrieved 2016/10/07.
• 3、 Yu, Xudong,Lin, Hai,Cai, Zunsheng,Lin, Huakuan. "Color responses of novel receptors for AcO- and a test paper for AcO- in pure aqueous solution". . p. 8615 - 8618. Retrieved 2008/03/30.