1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-

Base Information

Chemical Name:1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-
CAS No.:95853-92-2
Molecular Formula:C20H21ClN2O2
Molecular Weight:356.84600
Hs Code.:
Mol file:95853-92-2.mol

Synonyms:1-methyl-2-(3-pyridyl)-3-(5-carboxypentyl)-5-chloroindole;1-methyl-2-(pyridin-3-yl)-3-(5-carboxypentyl)-5-chloroindole;3-(5-carboxypentyl)-5-chloro-1-methyl-2-(3-pyridyl)indole;6-(5-Chloro-1-methyl-2-pyridin-3-yl-1H-indol-3-yl)-hexanoic acid;

Suppliers and Price of 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

CSNpharm
CGS15435
10mg
$ 2308.00

CSNpharm
CGS15435
5mg
$ 1442.00

Total 8 raw suppliers

Chemical Property of 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-

Chemical Property:

PSA：55.12000
LogP:5.08120

Purity/Quality:

97% ^*data from raw suppliers

CGS15435 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses CGS 15435, is a thromboxane (TxA2) synthetase inhibitor. It has also high selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.

Technology Process of 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)-

There total 1 articles about 1H-Indole-3-hexanoic acid, 5-chloro-1-methyl-2-(3-pyridinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(5-carbamoylpentyl)-5-chloro-1-methyl-2-(pyridin-3-yl)indole

: 95853-92-2
3-(5-carboxypentyl)-5-chloro-1-methyl-2-(pyridin-3-yl)indole

Guidance literature:: In hydrogenchloride;

Reference yield: 52.0%

: 95853-92-2
3-(5-carboxypentyl)-5-chloro-1-methyl-2-(pyridin-3-yl)indole

: 6-amino-2-<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>hexanoic acid benzyl ester

: 158387-23-6
2-<<1-(carboxymethyl)-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-idol-3-yl>pentanoyl>amino>hexanoic acid dibenzyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; for 16h;
DOI:10.1021/jm00038a011

Reference yield:

: 95853-92-2
3-(5-carboxypentyl)-5-chloro-1-methyl-2-(pyridin-3-yl)indole

: 158387-27-0
<<1-<<(benzyloxy)carbonyl>methyl>-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl>amino>-6-<<5-<5-chloro-1-methyl-2-(3-pyridinyl)-1H-indol-3-yl>pentanoyl>(2-hydroxyethyl)amino>hexanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDCl, DMAP

2: 1.7 g / Et₃N / dimethylformamide / 18 h / 60 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00038a011