2,2-dimethyl-7-[3-(3-phenylpropyl)thiophen-2-yl]heptanoic acid

Base Information

• Chemical Name: 2,2-dimethyl-7-[3-(3-phenylpropyl)thiophen-2-yl]heptanoic acid
• CAS No.: 142422-79-5
• Molecular Formula: C₂₂H₃₀O₂S
• Molecular Weight: 358.545
• Mol file: 142422-79-5.mol

Synonyms:RP66153

Chemical Property of 2,2-dimethyl-7-[3-(3-phenylpropyl)thiophen-2-yl]heptanoic acid

Chemical Property:

• Vapor Pressure: 9.86E-11mmHg at 25°C
• Boiling Point: 497.9°C at 760 mmHg
• Flash Point: 254.9°C
• PSA: 65.54000
• Density: 1.08g/cm³
• LogP: 6.13710

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,2-dimethyl-7-[3-(3-phenylpropyl)thiophen-2-yl]heptanoic acid

There total 5 articles about 2,2-dimethyl-7-[3-(3-phenylpropyl)thiophen-2-yl]heptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-phenyl-3-(thiophen-3-yl)propan-1-one (71778-01-3) → 2,2-dimethyl-7-<3-(3-phenylpropyl)-2-thienyl>heptanoic acid (142422-79-5)

Guidance literature:

Multi-step reaction with 6 steps

1: 76 percent / H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

2: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

3: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

4: 76 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

5: 89 percent / 1,1'-carbonyldiimidazole, allyl bromide / acetonitrile / 2 h / Heating

6: 1.) LDA, HMPA / 1.) THF, hexane, 50 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; tin(IV) chloride; hydrazine hydrate; allyl bromide; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In diethyl ether; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jm00095a011

Reference yield:

3-(3-phenylpropyl)thiophene (120245-35-4) → 2,2-dimethyl-7-<3-(3-phenylpropyl)-2-thienyl>heptanoic acid (142422-79-5)

Guidance literature:

Multi-step reaction with 5 steps

1: SnCl₄ / 1,2-dichloro-ethane / 1 h / Ambient temperature

2: H₂NNH₂*H₂O, KOH / various solvent(s) / 4 h / 210 °C

3: 76 percent / LiAlH₄ / diethyl ether / 2 h / Ambient temperature

4: 89 percent / 1,1'-carbonyldiimidazole, allyl bromide / acetonitrile / 2 h / Heating

5: 1.) LDA, HMPA / 1.) THF, hexane, 50 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; lithium aluminium tetrahydride; tin(IV) chloride; hydrazine hydrate; allyl bromide; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In diethyl ether; 1,2-dichloro-ethane; acetonitrile;

DOI:10.1021/jm00095a011

Reference yield:

5-<3-(3-phenylpropyl)-2-thienyl>-1-pentanol (142423-02-7) → 2,2-dimethyl-7-<3-(3-phenylpropyl)-2-thienyl>heptanoic acid (142422-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / 1,1'-carbonyldiimidazole, allyl bromide / acetonitrile / 2 h / Heating

2: 1.) LDA, HMPA / 1.) THF, hexane, 50 deg C, 2 h, 2.) THF, hexane, 25 deg C, 2 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; allyl bromide; 1,1'-carbonyldiimidazole; lithium diisopropyl amide; In acetonitrile;

DOI:10.1021/jm00095a011

upstream raw materials:

1-phenyl-3-(thiophen-3-yl)propan-1-one

3-(3-phenylpropyl)thiophene

5-<3-(3-phenylpropyl)-2-thienyl>-1-pentanol

5-<3-(3-phenylpropyl)-2-thienyl>pentanoic acid

Refernces