3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide

Base Information

Chemical Name:3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide
CAS No.:95925-01-2
Molecular Formula:C18H17NO3
Molecular Weight:295.338
Hs Code.:
DSSTox Substance ID:DTXSID70351157
Mol file:95925-01-2.mol

Synonyms:WAY-225212;DTXSID70351157;3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide

Suppliers and Price of 3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:295.12084340
Heavy Atom Count:22
Complexity:390

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1OC2=C(O1)C=C(C=C2)C=CC(=O)NCCC3=CC=CC=C3

Technology Process of 3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide

There total 4 articles about 3-(2H-1,3-Benzodioxol-5-yl)-N-(2-phenylethyl)prop-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 64-04-0
phenethylamine

: 2373-80-0,38489-76-8
3,4-methylenedioxy-trans-cinnamic acid

: 95925-01-2
(E)-3-(benzo[d][1,3]dioxol-5-yl)-N-phenethylacrylamide

Guidance literature:: 3,4-methylenedioxy-trans-cinnamic acid; With tris(2,2,2-trifluoroethyl) borate; In acetonitrile; at 20 ℃; for 0.166667h; Inert atmosphere; Sealed tube; Green chemistry;

phenethylamine; In acetonitrile; at 100 ℃; for 24h; Inert atmosphere; Sealed tube; Green chemistry;
DOI:10.1016/j.ejps.2018.10.028

Reference yield: 45.0%

: 120-57-0,30024-74-9
piperonal

: 73818-55-0,15596-07-3
Bestmann ylide

: 64-04-0
phenethylamine

: 95925-01-2
(E)-3-(benzo[d][1,3]dioxol-5-yl)-N-phenethylacrylamide

Guidance literature:: In toluene; for 24h; Heating;
DOI:10.1039/b105745f

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 95925-01-2
(E)-3-(benzo[d][1,3]dioxol-5-yl)-N-phenethylacrylamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / 90 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 0.33 h / Cooling with ice

2.2: 20 °C / Cooling with ice

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; 1.1: |Knoevenagel Condensation;
DOI:10.1016/j.ejmech.2017.11.066