3-CHLORO-5,6-DIMETHYLPYRIDAZINE-4-CARBONITRILE

Base Information

• Chemical Name: 3-CHLORO-5,6-DIMETHYLPYRIDAZINE-4-CARBONITRILE
• CAS No.: 93824-72-7
• Molecular Formula: C7H6ClN3
• Molecular Weight: 167.5956
• Hs Code.: 2933990090
• Mol file: 93824-72-7.mol

Synonyms:3-chloro-5,6-dimethylpyridazin-4-carbonitrile;3-Chlor-5,6-dimethyl-pyridazin-4-carbonitril;3-chloro-5,6-dimethyl-pyridazine-4-carbonitrile;

Chemical Property of 3-CHLORO-5,6-DIMETHYLPYRIDAZINE-4-CARBONITRILE

Chemical Property:

• Vapor Pressure: 1.56E-06mmHg at 25°C
• Melting Point: 79-80 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 397.7°Cat760mmHg
• PKA: -1.30±0.10(Predicted)
• Flash Point: 194.3°C
• PSA: 49.57000
• Density: 1.29g/cm³
• LogP: 1.61848

Purity/Quality:

97% ^*data from raw suppliers

3-chloro-5,6-dimethylpyridazine-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-CHLORO-5,6-DIMETHYLPYRIDAZINE-4-CARBONITRILE

There total 1 articles about 3-CHLORO-5,6-DIMETHYLPYRIDAZINE-4-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

5,6-dimethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile (40380-36-7) → 3-chloro-5,6-dimethylpyridazine-4-carbonitrile (93824-72-7)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

DOI:10.1080/10426500802353213

Reference yield: 75.0%

3-chloro-5,6-dimethylpyridazine-4-carbonitrile (93824-72-7) + thiophenol (108-98-5) → 5,6-dimethyl-3-(phenylthio)pyridazine-4-carbonitrile (93824-73-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 110 ℃; for 3.5h;

DOI:10.1135/cccc19841722

Reference yield:

3-chloro-5,6-dimethylpyridazine-4-carbonitrile (93824-72-7) → 5-amino-N-(2,3-difluoro-4-methoxybenzyl)-3,4-dimethylthieno[2,3-c]pyridazine-6-carboxamide

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / methanol; water / 0.5 h / 150 °C / Microwave irradiation; Inert atmosphere

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/acsmedchemlett.6b00461

upstream raw materials:

5,6-dimethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile

Downstream raw materials:

5,6-dimethyl-3-(phenylthio)pyridazine-4-carbonitrile

5-amino-4-methyl-3-(morpholinomethyl)-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno[2,3-c]pyridazine-6-carboxamide

5-amino-3,4-dimethyl-N-(4-((trifluoromethyl)sulfonyl)benzyl)thieno-[2,3-c]pyridazine-6-carboxamide

C₁₇H₁₈N₄OS₂

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 93824-72-7 3-CHLORO-5,6-DIMETHYLPYRIDAZINE-4-CARBONITRILE

Send

Send

Metric Ton KG G Pound L ML

Send

Send