Clocinizine

Base Information

Chemical Name:Clocinizine
CAS No.:298-55-5
Molecular Formula:C₂₆H₂₇ClN₂
Molecular Weight:402.967
Hs Code.:
UNII:8HQJ711KH8
Nikkaji Number:J5.465H
Wikipedia:Clocinizine
Wikidata:Q5134770
NCI Thesaurus Code:C77435
ChEMBL ID:CHEMBL3989706
Mol file:298-55-5.mol

Synonyms:Clocinizine;Chlorcinnarizine;Chlorcinnazine;chlorocinnarizine;298-55-5;Cliocinizine;Clocinizina;Clocinizinum;Clocinizine [INN:DCF];Clocinizinum [INN-Latin];Clocinizina [INN-Spanish];UNII-8HQJ711KH8;8HQJ711KH8;1-[(4-chlorophenyl)-phenylmethyl]-4-[(E)-3-phenylprop-2-enyl]piperazine;1-(4-Chlor-alpha-phenylbenzyl)-4-cinnamylpiperazin;1-(p-Chloro-alpha-phenylbenzyl)-4-cinnamylpiperazine;1-(p-Chloro-.alpha.-phenylbenzyl)-4-cinnamylpiperazine;Clocinizine [DCF:INN];CLOCINIZINE [MI];CLOCINIZINE [INN];SCHEMBL30363;C26H27ClN2;CLOCINIZINE [WHO-DD];CHEMBL3989706;C26-H27-Cl-N2;CHEBI:135647;ZSQANMZWGKYDER-JXMROGBWSA-N;AKOS001388273;UPCMLD0ENAT5886944:001;SR-01000944962;Q5134770;SR-01000944962-1;Z44528386;1-[(4-Chlorophenyl)phenylmethyl]-4-(3-phenyl-2-propen-1-yl)piperazine;1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]piperazine #;PIPERAZINE, 1-((4-CHLOROPHENYL) PHENYLMETHYL)-4-(3-PHENYL-2-PROPEN-1-YL)-

Suppliers and Price of Clocinizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 10 raw suppliers

Chemical Property of Clocinizine

Chemical Property:

Vapor Pressure:1.67E-11mmHg at 25°C
Boiling Point:534.5°Cat760mmHg
Flash Point:277.1°C
PSA：6.48000
Density:1.154g/cm³
LogP:5.63620
XLogP3:6.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:402.1862766
Heavy Atom Count:29
Complexity:479

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl
Isomeric SMILES:C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl

Technology Process of Clocinizine

There total 5 articles about Clocinizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 303-26-4
N-(4-chlorobenzhydryl)piperazine

: 4392-24-9
3-bromo-1-phenyl-1-propenyl bromide

: 298-55-5
1-[(4-chlorophenyl)(phenyl)methyl]-4-cinnamylpiperazine

Guidance literature:: N-(4-chlorobenzhydryl)piperazine; With sodium hydroxide; In tetrahydrofuran; water; for 0.25h;

3-bromo-1-phenyl-1-propenyl bromide; In tetrahydrofuran; water; at 20 - 70 ℃; for 2h;
DOI:10.1007/s00044-011-9556-x

Reference yield:

: 119-56-2
(4-chlorophenyl)phenylmethanol

: 298-55-5
1-[(4-chlorophenyl)(phenyl)methyl]-4-cinnamylpiperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; calcium chloride / water / 4 h / 20 °C / Reflux

2.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux

3.1: sodium hydroxide / tetrahydrofuran; water / 0.25 h

3.2: 2 h / 20 - 70 °C

With hydrogenchloride; tetra-(n-butyl)ammonium iodide; potassium carbonate; calcium chloride; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1007/s00044-011-9556-x

Reference yield:

: 134-83-8,60035-71-4
1-chloro-4-(chloro(phenyl)methyl)benzene

: 298-55-5
1-[(4-chlorophenyl)(phenyl)methyl]-4-cinnamylpiperazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / tetrahydrofuran / 8 h / Reflux

2.1: sodium hydroxide / tetrahydrofuran; water / 0.25 h

2.2: 2 h / 20 - 70 °C

With tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; water;
DOI:10.1007/s00044-011-9556-x