Technology Process of 2',3'-dideoxy-3'-fluoroaristeromycin
There total 12 articles about 2',3'-dideoxy-3'-fluoroaristeromycin which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 48 percent / hydrogen fluoride-pyridine, N-bromosuccinimide / tetrahydrofuran / 1.) O deg C, 30 min, 2.) room temp., 2 h
2: 88 percent / tributyltin hydride, α,α'-azobisisobutyronitrile / benzene / 0.17 h / Heating
3: 100 percent / 2N HCl / 8 h / Heating
4: triethylamine
5: 2.) ammonia-methanol
With
hydrogenchloride; N-Bromosuccinimide; ammonia-methanol; azobisisobutyronitrile; tri-n-butyl-tin hydride; pyridine hydrogenfluoride; triethylamine;
In
tetrahydrofuran; benzene;
DOI:10.1248/cpb.42.183
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 9 percent / triphenylphosphine, iodine, imidazole / toluene / 4 h / Heating
2: 100 percent / tributyltin hydride, α,α'-azobisisobutyronitrile / benzene / 0.33 h / Heating
3: 100 percent / 2N HCl / 8 h / Heating
4: triethylamine
5: 2.) ammonia-methanol
With
1H-imidazole; hydrogenchloride; ammonia-methanol; azobisisobutyronitrile; iodine; tri-n-butyl-tin hydride; triethylamine; triphenylphosphine;
In
toluene; benzene;
DOI:10.1248/cpb.42.183
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 83 percent / dimethylformamide / 2 h / Ambient temperature
2: 37 percent / imidazole / dimethylformamide / 10 h / Ambient temperature
3: 1.) phenylchlorothionocarbonate, 2.) tributyltin hydride, α,α'-azobisisobutyronitrile / 1.) CH2Cl2, room temp., 15 min
4: tetrabutylammonium fluoride
5: 28percent ammonium hydroxide
With
1H-imidazole; ammonium hydroxide; azobisisobutyronitrile; tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; phenylcarbonochloridothioate;
In
N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.183
