N-{(1S,2S)-1-benzyl-3-[1-(biphenyl-4-ylmethyl)-2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazino]-2-hydroxypropyl}-N~2~-(methoxycarbonyl)-L-valinamide

Base Information

Chemical Name:N-{(1S,2S)-1-benzyl-3-[1-(biphenyl-4-ylmethyl)-2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazino]-2-hydroxypropyl}-N~2~-(methoxycarbonyl)-L-valinamide
CAS No.:191594-60-2
Molecular Formula:C38H51N5O7
Molecular Weight:689.8408
Hs Code.:

N-{(1S,2S)-1-benzyl-3-[1-(biphenyl-4-ylmethyl)-2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazino]-2-hydroxypropyl}-N~2~-(methoxycarbonyl)-L-valinamide

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{(1S,2S)-1-benzyl-3-[1-(biphenyl-4-ylmethyl)-2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazino]-2-hydroxypropyl}-N~2~-(methoxycarbonyl)-L-valinamide

Chemical Property:

Boiling Point:°Cat760mmHg
Flash Point:°C
Density:1.172g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-{(1S,2S)-1-benzyl-3-[1-(biphenyl-4-ylmethyl)-2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazino]-2-hydroxypropyl}-N~2~-(methoxycarbonyl)-L-valinamide

There total 9 articles about N-{(1S,2S)-1-benzyl-3-[1-(biphenyl-4-ylmethyl)-2-{(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}hydrazino]-2-hydroxypropyl}-N~2~-(methoxycarbonyl)-L-valinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3218-36-8
4-Phenylbenzaldehyde

: 191594-60-2
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 100 percent / ethanol / 4 h / Heating

2: 62 percent / H₂ / 10percent Pd/C / methanol

3: 62 percent / propan-2-ol / 16 h / 80 °C

4: 95 percent / aq. K₂CO₃ / methanol / 3 h / Heating

5: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / 1.) DMF, 30 min, 2.) DMF, RT, 3 h

6: 100 percent / 4N HCl / dioxane; methanol / 3 h / Ambient temperature

7: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, 2.) N-methylmorpholine / 1.) DMF, 15 min, 2.) DMF, 16 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; isopropyl alcohol;
DOI:10.1021/jm970873c

Reference yield:

: N'-[1-Biphenyl-4-yl-meth-(E)-ylidene]-hydrazinecarboxylic acid tert-butyl ester

: 191594-60-2
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 62 percent / H₂ / 10percent Pd/C / methanol

2: 62 percent / propan-2-ol / 16 h / 80 °C

3: 95 percent / aq. K₂CO₃ / methanol / 3 h / Heating

4: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / 1.) DMF, 30 min, 2.) DMF, RT, 3 h

5: 100 percent / 4N HCl / dioxane; methanol / 3 h / Ambient temperature

6: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, 2.) N-methylmorpholine / 1.) DMF, 15 min, 2.) DMF, 16 h

With 4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; isopropyl alcohol;
DOI:10.1021/jm970873c

Reference yield:

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 191594-60-2
((S)-1-{N'-Biphenyl-4-ylmethyl-N'-[(2S,3S)-2-hydroxy-3-((S)-2-methoxycarbonylamino-3-methyl-butyrylamino)-4-phenyl-butyl]-hydrazinocarbonyl}-2,2-dimethyl-propyl)-carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride, 1-hydroxybenzotriazole, Et₃N / 1.) DMF, 30 min, 2.) DMF, RT, 3 h

2: 100 percent / 4N HCl / dioxane; methanol / 3 h / Ambient temperature

3: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, 2.) N-methylmorpholine / 1.) DMF, 15 min, 2.) DMF, 16 h

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol;
DOI:10.1021/jm970873c