Technology Process of Germane, (3-chloro-1-propynyl)triphenyl-
There total 1 articles about Germane, (3-chloro-1-propynyl)triphenyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
n-butyllithium;
In
tetrahydrofuran;
BuLi in hexane was cautiously added under N2 at -100°C to a stirred soln. of propargylic chloride in THF, after 10 min Ph3GeCl was added, mixt. was stirred at -60°C for 0.5 h, allowed to warm to room temp.; mixt. was poured into satd. aq. NH4Cl, extd. with 1:1 ether-pentane, combined exts. were washed with water, dried over MgSO4, evapd. in vacuo;
DOI:10.1016/0022-328X(84)80703-2
- Guidance literature:
-
In
tetrahydrofuran;
propargylic chloride was added under N2 at -60°C to a soln. of EtCu in THF, mixt. was stirred for 1 h at -60°C; purity of the product >=95%; mixt. was poured into satd. aq. NH4Cl containing NaCN, extd. with 1:1 ether-pentane, combined exts. were washed with water, dried over MgSO4, solvent was evapd. in vacuo, residue crystd. from methanol or purified by column chromy. (Al2O3, hexane);
DOI:10.1016/0022-328X(84)80703-2
- Guidance literature:
-
In
tetrahydrofuran;
propargylic chloride was added under N2 at -60°C to a soln. of i-PrCu in THF, mixt. was stirred for 1 h at -60°C; purity of the product >=95%; mixt. was poured into satd. aq. NH4Cl containing NaCN, extd. with 1:1 ether-pentane, combined exts. were washed with water, dried over MgSO4, solvent was evapd. in vacuo, residue crystd. from methanol or purified by column chromy. (Al2O3, hexane);
DOI:10.1016/0022-328X(84)80703-2
