Benzeneethanesulfonamide, b-oxo-

Base Information

• Chemical Name: Benzeneethanesulfonamide, b-oxo-
• CAS No.: 96355-38-3
• Molecular Formula: C8H9NO3S
• Molecular Weight: 199.23
• Mol file: 96355-38-3.mol

Synonyms:2-Oxo-2-phenyl-ethanesulfonic acid amide;2-Oxo-2-phenyl-aethansulfonsaeure-amid;

Chemical Property of Benzeneethanesulfonamide, b-oxo-

Chemical Property:

• Melting Point: 159-160 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 402.6±47.0 °C(Predicted)
• PSA: 85.61000
• Density: 1.367±0.06 g/cm3(Predicted)
• LogP: 1.93890

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanesulfonamide, b-oxo-

There total 5 articles about Benzeneethanesulfonamide, b-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-styrenyloxytrimethylsilane (13735-81-4) → 2-oxo-2-phenylethane-1-sulfonamide (96355-38-3)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; sulphamoyl chloride; triethylamine; In acetonitrile; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.9b02062

Reference yield: 50.0%

6-phenyl-2-(p-tolyl)-1,4,3-oxathiazine-4,4-dioxide (98847-28-0) → 2-oxo-2-phenylethane-1-sulfonamide (96355-38-3) + p-Toluic acid (99-94-5)

Guidance literature:

With hydrogenchloride; In acetic acid; for 48h; Heating;

Reference yield:

6-phenyl-2-(p-tolyl)-1,4,3-oxathiazine-4-oxide (98847-18-8) → 2-oxo-2-phenylethane-1-sulfonamide (96355-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: MCPBA / CH₂Cl₂ / 8 h / Ambient temperature

2: 50 percent / conc. HCl / acetic acid / 48 h / Heating

With hydrogenchloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetic acid;

upstream raw materials:

6-phenyl-2-(p-tolyl)-1,4,3-oxathiazine-4,4-dioxide

6-phenyl-2-(p-tolyl)-1,4,3-oxathiazine-4-oxide

phenylacetylene

1-styrenyloxytrimethylsilane

Downstream raw materials:

N-(Benzoylmethylsulfonyl)-N'-phenylharnstoff

3,5-Diphenyl-2H-1,2-thiazin-1,1-dioxid