DELTA-AMINOLEVULINATE DEHYDRATASE

Base Information

• Chemical Name: DELTA-AMINOLEVULINATE DEHYDRATASE
• CAS No.: 9036-37-7
• Molecular Weight: 0
• Mol file: 9036-37-7.mol

Synonyms:5-Aminolevulinatedehydrase; 5-Aminolevulinate dehydratase; 5-Aminolevulinate hydrolyase;5-Aminolevulinic acid dehydrase; 5-Aminolevulinic acid dehydratase;5-Aminolevulinic dehydratase; 5-Levulinic acid dehydratase; Aminolevulinatedehydrase; Aminolevulinate dehydratase; Aminolevulinic acid dehydratase;Aminolevulinic acid dehydrogenase; Aminolevulinic dehydratase; E.C. 4.2.1.24;Gene ALAD protein; Porphobilinogen synthase; Porphobilinogen synthetase; g-Aminolevulinic acid dehydratase;d-Aminolevulinate dehydrase; d-Aminolevulinate dehydratase; d-Aminolevulinic acid dehydrase; d-Aminolevulinic acid dehydratase;d-Aminolevulinic dehydratase

Chemical Property of DELTA-AMINOLEVULINATE DEHYDRATASE

Chemical Property:

• Appearance/Colour: lyophilized powder
• Storage Temp.: −20°C

Purity/Quality:

99% ^*data from raw suppliers

DELTA-AMINOLEVULINATE DEHYDRATASE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Total 1 MSDS from other Authors

Useful:

Refernces

Lead poisoning and the inactivation of 5-aminolevulinate dehydratase as modeled by the tris(2-mercapto-1-phenylimidazolyl)hydroborato lead complex, {[Tm(Ph)]Pb}[ClO₄] [14]

10.1021/ja001530y

The research investigates the inactivation of 5-aminolevulinate dehydratase (ALAD) by lead, focusing on the reactivity of a synthetic analogue towards PbII. The study uses a series of complexes with tris(mercaptoarylimidazolyl)borate ligands to model the binding of the zinc center to the three cysteine residues in ALAD. The researchers observed that lead readily displaces zinc in these complexes, forming a monomeric trigonal pyramidal structure similar to the active site of PbII-ALAD. The study also determined that the preference of the ligand to coordinate PbII over ZnII is approximately 500:1, significantly higher than the relative affinity of these metals in human erythrocyte ALAD. However, zinc can displace lead in the presence of iodide, suggesting a potential method for lead sequestration. The findings provide insights into the coordination chemistry of lead and zinc and its impact on ALAD inactivation, contributing to the understanding of lead toxicity.