2H-2-Benzazepine-2-carboxylic acid, 1,3,4,5-tetrahydro-7,8-dimethoxy-5-[(phenylmethoxy)methyl]-, methyl ester

Base Information

Chemical Name:2H-2-Benzazepine-2-carboxylic acid, 1,3,4,5-tetrahydro-7,8-dimethoxy-5-[(phenylmethoxy)methyl]-, methyl ester
CAS No.:96422-79-6
Molecular Formula:C₂₂H₂₇NO₅
Molecular Weight:385.46
Hs Code.:

Synonyms:

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Chemical Property of 2H-2-Benzazepine-2-carboxylic acid, 1,3,4,5-tetrahydro-7,8-dimethoxy-5-[(phenylmethoxy)methyl]-, methyl ester

Chemical Property:

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Technology Process of 2H-2-Benzazepine-2-carboxylic acid, 1,3,4,5-tetrahydro-7,8-dimethoxy-5-[(phenylmethoxy)methyl]-, methyl ester

There total 8 articles about 2H-2-Benzazepine-2-carboxylic acid, 1,3,4,5-tetrahydro-7,8-dimethoxy-5-[(phenylmethoxy)methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 96422-74-1
[4-Benzyloxy-3-(3,4-dimethoxy-phenyl)-butyl]-hydroxymethyl-carbamic acid methyl ester

: 96422-79-6
5-Benzyloxymethyl-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid methyl ester

Guidance literature:: With toluene-4-sulfonic acid; In benzene; Yield given;

Reference yield:

: 15964-79-1
methyl (3,4-dimethoxyphenyl)acetate

: 96422-79-6
5-Benzyloxymethyl-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 72 percent / Triton B

2: 92 percent / lithium borohydride / tetrahydrofuran / Ambient temperature

3: 84 percent / NaH / tetrahydrofuran; dimethylformamide / Ambient temperature

4: 81 percent / 40percent NaOH / ethanol / Heating

5: 1.) Curtius rearrangement, 2.) methanolysis

6: 92 percent / 25percent NaOH / dioxane / 15 h / Ambient temperature

7: p-toluenosulfonic acid / benzene

With sodium hydroxide; lithium borohydride; N-benzyl-trimethylammonium hydroxide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; benzene;

Reference yield:

: 100-44-7
benzyl chloride

: 96422-79-6
5-Benzyloxymethyl-7,8-dimethoxy-1,3,4,5-tetrahydro-benzo[c]azepine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / NaH / tetrahydrofuran; dimethylformamide / Ambient temperature

2: 81 percent / 40percent NaOH / ethanol / Heating

3: 1.) Curtius rearrangement, 2.) methanolysis

4: 92 percent / 25percent NaOH / dioxane / 15 h / Ambient temperature

5: p-toluenosulfonic acid / benzene

With sodium hydroxide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; benzene;