1-(3-Chlorophenyl)piperazine

Base Information Edit

Chemical Name:1-(3-Chlorophenyl)piperazine
CAS No.:6640-24-0
Molecular Formula:C10H13ClN2
Molecular Weight:196.68
Hs Code.:29339900
European Community (EC) Number:229-654-7
NSC Number:49307
UNII:REY0CNO998
DSSTox Substance ID:DTXSID9045138
Nikkaji Number:J227.960F
Wikipedia:Meta-Chlorophenylpiperazine
Wikidata:Q286112
Pharos Ligand ID:M84J2R7NRZ5M
Metabolomics Workbench ID:53539
ChEMBL ID:CHEMBL478
Mol file:6640-24-0.mol

Synonyms:1-(3-chlorophenyl)piperazine;1-(3-chlorophenyl)piperazine dihydrochloride;1-(3-chlorophenyl)piperazine monohydrochloride;1-(m-chlorophenyl)piperazine;1-3-CPP;3-chlorophenylpiperazine;dihydrochloro phenyl piperazine;m-chlorophenylpiperazine;m-CPP;meta-chlorophenylpiperazine

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 1-(3-Chlorophenyl)piperazine Edit

Chemical Property:

Appearance/Colour:clear colorless to light yellow oily liquid
Vapor Pressure:0.000112mmHg at 25°C
Melting Point:210-214 °C
Refractive Index:1.598 - 1.600
Boiling Point:336.4 °C at 760 mmHg
PKA:8.85±0.10(Predicted)
Flash Point:157.2 °C
PSA：15.27000
Density:1.159 g/cm³
LogP:2.14340
Storage Temp.:-20?C Freezer, Under Inert Atmosphere
Solubility.:Chloroform (Slightly), Methanol (Sparingly)
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:196.0767261
Heavy Atom Count:13
Complexity:157

Purity/Quality:

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38
Safety Statements: 26-36/37/39-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)C2=CC(=CC=C2)Cl
Recent ClinicalTrials:M-CPP and Fenfluramine in Cocaine Addicts - 3
Uses It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone. The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone. It is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.

Technology Process of 1-(3-Chlorophenyl)piperazine

There total 13 articles about 1-(3-Chlorophenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 6640-24-0
N-(m-chlorophenyl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 90.0%

: 110-85-0
piperazine

: 541-73-1
1,3-Dichlorobenzene

: 6640-24-0
N-(m-chlorophenyl)piperazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2-dicyclohexylphosphino-2′,6′-di-i-propoxy-1,1′-biphenyl; sodium t-butanolate; In 1,4-dioxane; at 100 ℃; for 0.166667h; Temperature;
DOI:10.1021/acs.orglett.6b02591