Isoxazole, 5-(3-nitrophenyl)-3-phenyl-

Base Information

• Chemical Name: Isoxazole, 5-(3-nitrophenyl)-3-phenyl-
• CAS No.: 964-91-0
• Molecular Formula: C15H10N2O3
• Molecular Weight: 266.25200
• Mol file: 964-91-0.mol

Synonyms:3-Phenyl-5-(3-nitro-phenyl)-isoxazol;5-(3-Nitro-phenyl)-3-phenyl-isoxazol;3-Phenyl-5-(m-nitrophenyl)-isoxazol;3-phenyl-5-(m-nitrophenyl)-isoxazole;

Chemical Property of Isoxazole, 5-(3-nitrophenyl)-3-phenyl-

Chemical Property:

• PSA: 71.85000
• LogP: 4.44000

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Isoxazole, 5-(3-nitrophenyl)-3-phenyl-

There total 17 articles about Isoxazole, 5-(3-nitrophenyl)-3-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1-(3-nitrophenyl)-3-phenylprop-2-yn-1-one (16616-39-0) → 5-(3-nitrophenyl)-3-phenylisoxazole (964-91-0)

Guidance literature:

With trimethylsilylazide; In Trichloroethylene; at 20 ℃; for 12h;

DOI:10.1039/c6cc02047j

Reference yield:

3-(3-nitrophenyl)-1-phenylprop-2-yn-1-one (129972-90-3) → 5-(3-nitrophenyl)-3-phenylisoxazole (964-91-0)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; In water; at 60 ℃; for 5h;

DOI:10.1039/c9cy01335k

Reference yield:

m-nitrobenzalacetophenone dibromide (6968-99-6) → 5-(3-nitrophenyl)-3-phenylisoxazole (964-91-0)

Guidance literature:

With hydrogenchloride; potassium hydroxide; hydroxylamine;

DOI:10.1021/ja01248a039

upstream raw materials:

benzonitrile oxide

3-nitrophenylacetylene

m-nitrobenzalacetophenone dibromide

5-(3-nitrophenyl)-3-phenyl-4,5-dihydroisoxazole

Downstream raw materials:

4-chloro-5-(3-nitro-phenyl)-3-phenyl-isoxazole