Josamycin

Base Information

• Chemical Name: Josamycin
• CAS No.: 16846-24-5
• Deprecated CAS: 11033-18-4,35414-05-2,39416-64-3,56689-45-3,801993-04-4
• Molecular Formula: C42H69 N O15
• Molecular Weight: 828.02
• European Community (EC) Number: 240-871-6
• UNII: HV13HFS217
• ChEMBL ID: CHEMBL224436
• Metabolomics Workbench ID: 43492
• NCI Thesaurus Code: C83851
• Nikkaji Number: J979B
• Wikidata: Q423369
• Wikipedia: Josamycin
• Mol file: 16846-24-5.mol

Synonyms:EN 141;EN-141;EN141;Josamycin;Josamycine;Kitasamycin A3;Leucomycin A3;Turimycin A5;Wilprafen

Chemical Property of Josamycin

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 131.5℃
• Refractive Index: 1.534
• Boiling Point: 877.8°Cat760mmHg
• PKA: 7.1 (40% aq methanol)
• Flash Point: 484.7°C
• PSA: 206.05000
• Density: 1.2g/cm³
• LogP: 3.01340
• Storage Temp.: 2-8°C
• Solubility.: Soluble in ethanol
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 14
• Exact Mass: 827.46672049
• Heavy Atom Count: 58
• Complexity: 1390

Purity/Quality:

99% ^*data from raw suppliers

Leucomycin A3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1CC=CC=CC(C(CC(C(C(C(CC(=O)O1)OC(=O)C)OC)OC2C(C(C(C(O2)C)OC3CC(C(C(O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O
• Isomeric SMILES: C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O
• Recent ClinicalTrials: Reduction of Spontaneous Prematurity by Antibiotic Treatment (Josamycin)
• Recent EU Clinical Trials: Réduction de la prématurité spontanée : Impact d'un traitement antibiotique (JOSAMYCINE) en cas de PCR positive pour Ureaplasma spp. et/ou Mycoplasma hominis dans le liquide amniotique
• Recent NIPH Clinical Trials: Analysis of vaginal and uterine microbiota of infertile and recurrent miscarriage patients
• Uses: Josamycin, is used as a macrolide antibiotic effective against a variety of pathogens. As a 16-membered ring macrolide antibiotic with antimicrobial activity against a wide range of pathogens. Josamycin can be particularly used in the treatment of Mycoplasma infection.Josamycin is used to study the modification of phagocytosis and cytokine production by macrolide antibiotics, immunomodulatory effects, the suppression of matrix metalloproteinase production as well as study bacteria protein synthesis at the level of the the 23S rRNA, 50S ribosomal subunit.
• Therapeutic Function: Antibiotic