Colchinoic acid

Base Information

• Chemical Name: Colchinoic acid
• CAS No.: 6714-14-3
• Molecular Formula: C21H23NO6
• Molecular Weight: 385.4104
• NSC Number: 406041
• DSSTox Substance ID: DTXSID70987718

Synonyms:Colchinoic acid;Allocolchicein;Allocolchiceine;Colchicic acid;Colchicinoic acid;6714-14-3;5H-Dibenzo(a,c)cycloheptene-3-carboxylic acid, 5-(acetylamino)-6,7-dihydro-9,10,11-trimethoxy-, (S)-;8-acetamido-13,14,15-trimethoxytricyclo[9.4.0.02,7]pentadeca-1(15),2(7),3,5,11,13-hexaene-5-carboxylic acid;NSC 406041;DTXSID70987718;ZAIRUODZMPTJLF-UHFFFAOYSA-N;HMS3355O02;NSC406041;NSC-406041;5H-Dibenzo[a, 5-(acetylamino)-6,7-dihydro-9,10,11-trimethoxy-, (S)-;5-(Acetylamino)-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c]cycloheptene-3-carboxylic acid, (S)-;5-[(1-Hydroxyethylidene)amino]-9,10,11-trimethoxy-6,7-dihydro-5H-dibenzo[a,c][7]annulene-3-carboxylic acid

Chemical Property of Colchinoic acid

Chemical Property:

• Vapor Pressure: 1.32E-18mmHg at 25°C
• Boiling Point: 665.3°Cat760mmHg
• Flash Point: 356.2°C
• Density: 1.31g/cm³
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 5
• Exact Mass: 385.15253745
• Heavy Atom Count: 28
• Complexity: 569

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=C1C=C(C=C3)C(=O)O)OC)OC)OC

Technology Process of Colchinoic acid

There total 6 articles about Colchinoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

colchicine (64-86-8,54192-66-4) → allocolchicinic acid (6714-14-3)

Guidance literature:

With sodium methylate; In methanol; at 65 ℃; for 4h;

DOI:10.1055/s-0037-1610673

Reference yield:

(7S)-isocolchicine (518-12-7) → allocolchicinic acid (6714-14-3)

Guidance literature:

With methanol; water; sodium methylate;

DOI:10.1002/hlca.19480310322

Reference yield:

colchiceine (477-27-0,1990-46-1) → allocolchicinic acid (6714-14-3)

Guidance literature:

With potassium hydroxide; water;

upstream raw materials:

colchicine

colchiceine

(7S)-isocolchicine

Downstream raw materials:

(-)-(7S)-allocolchicine

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