Methyll-bromo-cyclopropanecarboxylate

Base Information

• Chemical Name: Methyll-bromo-cyclopropanecarboxylate
• CAS No.: 96999-01-8
• Molecular Formula: C5H7BrO2
• Molecular Weight: 179.013
• Hs Code.: 2916209090
• Mol file: 96999-01-8.mol

Synonyms:Methyl 1-Bromocyclopropanecarboxylate;

Chemical Property of Methyll-bromo-cyclopropanecarboxylate

Chemical Property:

• Boiling Point: 151℃
• Flash Point: 45℃
• PSA: 26.30000
• Density: 1.727
• LogP: 1.08690
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl1-Bromocyclopropanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyll-bromo-cyclopropanecarboxylate

There total 2 articles about Methyll-bromo-cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 2,4-dibromobutanoate (29547-04-4,70288-65-2) → 1-(1-bromocyclopropyl)formic acid methyl ester (96999-01-8)

Guidance literature:

With sodium hydride; In propylene glycol; at 100 ℃; for 0.5h;

Reference yield: 91.4%

methyl 2-bromo-4-chlorobutyrate (24666-02-2) → 1-(1-bromocyclopropyl)formic acid methyl ester (96999-01-8)

Guidance literature:

With sodium; In ethylene glycol; at 80 ℃; for 0.166667h;

Reference yield: 58.2%

5-(chloro(3-(((4-methoxybenzyl)oxy)methyl)-4-methylphenyl)methyl)-1,4-dimethyl-1H-benzo[d][1,2,3]triazole + 1-(1-bromocyclopropyl)formic acid methyl ester (96999-01-8) → methyl 1-((1,4-dimethyl-1H-benzo[d][1,2,3]triazol-5-yl)(3-(((4-methoxybenzyl)oxy)methyl)-4-methylphenyl)methyl)cyclopropanecarboxylate

Guidance literature:

1-(1-bromocyclopropyl)formic acid methyl ester; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

5-(chloro(3-(((4-methoxybenzyl)oxy)methyl)-4-methylphenyl)methyl)-1,4-dimethyl-1H-benzo[d][1,2,3]triazole; In tetrahydrofuran; for 0.75h; Inert atmosphere;

upstream raw materials:

methyl 2,4-dibromobutanoate

methyl 2-bromo-4-chlorobutyrate

Downstream raw materials:

1-Bromocyclopropanecarboxylic acid

(1-bromocyclopropyl)methanol

1-bromocyclopropanecarboxylamide

methyl 1-(2-methoxy-6-methylphenyl)cyclopropanecarboxylate

Refernces

• 1、 -. "Synthesis method of 1-(1-halogenated cyclopropyl) formic ether compound". Paragraph 0018-0019. . Retrieved 2017/06/08.
• 2、 Hoffmann, H. Martin R.,Eggert, Ulrike,Walenta, Angela,Weineck, Edeltraut,Schomburg, Dietmar,et al.. "Trispirododecane-4,8,12-trione and Other Oligomers of Carbonylcyclopropane. The Organozinc Route". . p. 6096 - 6100. Retrieved 2007/10/02.