H-PRO-PHE-NH2 HCL

Base Information

• Chemical Name: H-PRO-PHE-NH2 HCL
• CAS No.: 97372-02-6
• Molecular Formula: C14H19N3O2.ClH
• Molecular Weight: 297.78100
• Mol file: 97372-02-6.mol

Synonyms:N-L-Prolyl-L-phenylalanin-amid, Hydrochlorid;amine pro phe amide HCl;N-L-prolyl-L-phenylalanine amide, hydrochloride;H-PRO-PHE-NH2 · HCl;

Chemical Property of H-PRO-PHE-NH2 HCL

Chemical Property:

• PSA: 84.22000
• LogP: 2.17320
• Storage Temp.: -15°C

Purity/Quality:

99%+, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-PRO-PHE-NH2 HCL

There total 3 articles about H-PRO-PHE-NH2 HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyloxycarbonyl-L-prolyl-L-phenylalanine amide (147489-80-3) → H-Pro-Phe-NH2 hydrochloride (97372-02-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

DOI:10.1016/S0968-0896(03)00068-3

Reference yield:

(S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide (88463-18-7,35150-06-2) → H-Pro-Phe-NH2 hydrochloride (97372-02-6)

Guidance literature:

Multi-step reaction with 3 steps

1: HCl / dioxane

2: 90.5 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0 - 4 °C

3: HCl / dioxane

With 4-methyl-morpholine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00068-3

Reference yield:

(S)-2-amino-3-phenylpropionamide hydrochloride (65864-22-4) → H-Pro-Phe-NH2 hydrochloride (97372-02-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.5 percent / N-methylmorpholine / tetrahydrofuran; dimethylformamide / 0 - 4 °C

2: HCl / dioxane

With 4-methyl-morpholine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(03)00068-3

upstream raw materials:

tert-butyloxycarbonyl-L-prolyl-L-phenylalanine amide

(S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide

(S)-2-amino-3-phenylpropionamide hydrochloride

Downstream raw materials:

[(S)-2-[(S)-2-((S)-1-Carbamoyl-2-phenyl-ethylcarbamoyl)-pyrrolidin-1-yl]-1-(4-hydroxy-2,6-dimethyl-benzyl)-2-oxo-ethyl]-carbamic acid tert-butyl ester