2,7-Dioxa-4,12-diazatridecan-13-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-3,8-dioxo-1-phenyl-, phenylmethyl ester, (S)-

Base Information

• Chemical Name: 2,7-Dioxa-4,12-diazatridecan-13-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-3,8-dioxo-1-phenyl-, phenylmethyl ester, (S)-
• CAS No.: 97868-85-4
• Molecular Formula: C₂₇H₃₅N₃O₈
• Molecular Weight: 529.59
• Mol file: 97868-85-4.mol

Synonyms:

Chemical Property of 2,7-Dioxa-4,12-diazatridecan-13-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-3,8-dioxo-1-phenyl-, phenylmethyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,7-Dioxa-4,12-diazatridecan-13-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-3,8-dioxo-1-phenyl-, phenylmethyl ester, (S)-

There total 1 articles about 2,7-Dioxa-4,12-diazatridecan-13-oic acid, 9-[[(1,1-dimethylethoxy)carbonyl]amino]-3,8-dioxo-1-phenyl-, phenylmethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

benzyl 2-hydroxyethylcarbamate (77987-49-6) + (2S)-4-(benzyloxycarbonyl)amino-2-(tert-butoxycarbonyl)aminobutyric acid (3350-20-7,47461-65-4,70882-68-7) → N-benzyloxycarbonyl-2-aminoethyl ester of Nα-tert-butyloxycarbonyl-Nγ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid (97868-85-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; for 24h; Ambient temperature;

Reference yield: 68.0%

N-benzyloxycarbonyl-2-aminoethyl ester of Nα-tert-butyloxycarbonyl-Nγ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid (97868-85-4) → hydrochloride of N-benzyloxycarbonyl-2-aminoethyl ester of Nγ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid (97868-87-6)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 1h; Ambient temperature;

Reference yield:

N-benzyloxycarbonyl-2-aminoethyl ester of Nα-tert-butyloxycarbonyl-Nγ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid (97868-85-4) → N-benzyloxycarbonyl-2-aminoethyl ester of Nα-palmitoyl-Nγ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid (97868-90-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / HCl / dioxane / 1 h / Ambient temperature

2: 61 percent / Et₃N / tetrahydrofuran / 20 h

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane;

upstream raw materials:

benzyl 2-hydroxyethylcarbamate

(2S)-4-(benzyloxycarbonyl)amino-2-(tert-butoxycarbonyl)aminobutyric acid

Downstream raw materials:

hydrochloride of N-benzyloxycarbonyl-2-aminoethyl ester of N^γ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid

N-benzyloxycarbonyl-2-aminoethyl ester of N^α-palmitoyl-N^γ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid

N-benzyloxycarbonyl-2-aminoethyl ester of N^α-palmitoyl-N^γ-benzyloxycarbonyl-L-α,γ-diaminobutyryl-N^γ-benzyloxycarbonyl-L-α,γ-diaminobutyric acid