7H-Pyrrolo[2,3-d]pyrimidin-7-amine, 6-(bromomethyl)-5,6-dihydro-2,4-dimethyl-N-[(4-nitrophenyl)methylene]- , monohydrobromide

Base Information

• Chemical Name: 7H-Pyrrolo[2,3-d]pyrimidin-7-amine, 6-(bromomethyl)-5,6-dihydro-2,4-dimethyl-N-[(4-nitrophenyl)methylene]- , monohydrobromide
• CAS No.: 98189-78-7
• Molecular Formula: C16H16BrN5O2.BrH
• Molecular Weight: 471.151
• Mol file: 98189-78-7.mol

Synonyms:

Chemical Property of 7H-Pyrrolo[2,3-d]pyrimidin-7-amine, 6-(bromomethyl)-5,6-dihydro-2,4-dimethyl-N-[(4-nitrophenyl)methylene]- , monohydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7H-Pyrrolo[2,3-d]pyrimidin-7-amine, 6-(bromomethyl)-5,6-dihydro-2,4-dimethyl-N-[(4-nitrophenyl)methylene]- , monohydrobromide

There total 4 articles about 7H-Pyrrolo[2,3-d]pyrimidin-7-amine, 6-(bromomethyl)-5,6-dihydro-2,4-dimethyl-N-[(4-nitrophenyl)methylene]- , monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(5-Allyl-2,6-dimethyl-pyrimidin-4-yl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine (98189-69-6) → (6-Bromomethyl-2,4-dimethyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine; hydrobromide (98189-78-7)

Guidance literature:

With bromine; In chloroform; for 0.75h; Ambient temperature;

DOI:10.1007/BF00506076

Reference yield:

4-nitrobenzaldehdye (555-16-8) → (6-Bromomethyl-2,4-dimethyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine; hydrobromide (98189-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / methanol / 0.67 h / Heating

2: 87 percent / Br₂ / CHCl₃ / 0.75 h / Ambient temperature

With bromine; In methanol; chloroform;

DOI:10.1007/BF00506076

Reference yield:

5-allyl-4-hydrazino-3,6-dimethylpyrimidine (98189-66-3) → (6-Bromomethyl-2,4-dimethyl-5,6-dihydro-pyrrolo[2,3-d]pyrimidin-7-yl)-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-amine; hydrobromide (98189-78-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / methanol / 0.67 h / Heating

2: 87 percent / Br₂ / CHCl₃ / 0.75 h / Ambient temperature

With bromine; In methanol; chloroform;

DOI:10.1007/BF00506076

upstream raw materials:

N-(5-Allyl-2,6-dimethyl-pyrimidin-4-yl)-N'-[1-(4-nitro-phenyl)-meth-(E)-ylidene]-hydrazine

4-nitrobenzaldehdye

5-allyl-4-hydrazino-3,6-dimethylpyrimidine

2,4-dimethyl-5-allyl-6-chloropyrimidine