Technology Process of 1,8-Naphthyridine-3-carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4-methylphenyl)thio]-4-oxo-
There total 13 articles about 1,8-Naphthyridine-3-carboxylic acid,
1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(4-methylphenyl)thio]-4-oxo- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 90 percent / KOH / ethanol / 2 h / Ambient temperature
2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C
3: 84 percent / conc. H2SO4 / 1 h / 50 - 55 °C
4: 98 percent / BF3-etherate / ice-cooling, then 50-60 deg C 30 min, then reflux 23 h
5: 96 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
6: 87 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
7: 83 percent / chloranil / toluene / 1.5 h / Heating
8: 97 percent / 1N-NaOH / dioxane / 1 h / Heating
With
potassium fluoride; potassium hydroxide; sodium hydroxide; ethanol; sulfuric acid; boron trifluoride diethyl etherate; chloranil; sodium hydride; sodium hydrogencarbonate;
In
1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570240520
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / NaHCO3 / dimethylformamide / 8 h / 110 - 120 °C
2: 87 percent / NaH, ethanol / toluene / 2 h / Ambient temperature
3: 83 percent / chloranil / toluene / 1.5 h / Heating
4: 97 percent / 1N-NaOH / dioxane / 1 h / Heating
With
sodium hydroxide; ethanol; chloranil; sodium hydride; sodium hydrogencarbonate;
In
1,4-dioxane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570240520
