4-AMino-1,3-dihydroisobenzofuran

Base Information

• Chemical Name: 4-AMino-1,3-dihydroisobenzofuran
• CAS No.: 98475-10-6
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.166
• Hs Code.: 2932999099
• Mol file: 98475-10-6.mol

Synonyms:4-Isobenzofuranamine,1,3-dihydro;1,3-dihydroisobenzofuran-4-ylamine;1,3-Dihydroisobenzofuran-4-amine;4-Amino-1,3-dihydroisobenzofuran;

Chemical Property of 4-AMino-1,3-dihydroisobenzofuran

Chemical Property:

• Boiling Point: 288.6±40.0 °C(Predicted)
• PKA: 4.19±0.20(Predicted)
• PSA: 35.25000
• Density: 1.208±0.06 g/cm3(Predicted)
• LogP: 1.88020

Purity/Quality:

99%, ^*data from raw suppliers

4-Amino-1,3-dihydroisobenzofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-AMino-1,3-dihydroisobenzofuran

There total 4 articles about 4-AMino-1,3-dihydroisobenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-nitro-1,3-dihydro-isobenzofuran (98475-08-2) → 1,3-dihydro-isobenzofuran-4-ylamine (98475-10-6)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.02.121

Reference yield:

4-nitro-1,3-dihydro-isobenzofuran (98475-08-2) + tin(II)chloride dihydrate → 1,3-dihydro-isobenzofuran-4-ylamine (98475-10-6)

Guidance literature:

With sodium hydroxide; In hydrogenchloride; water;

Reference yield:

1,2-bis(bromomethyl)-3-nitrobenzene (66126-16-7) → 1,3-dihydro-isobenzofuran-4-ylamine (98475-10-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / alumina; H₂O / toluene / 2 h / 120 °C

2: 100 percent / hydrogen / Raney Ni / tetrahydrofuran

With aluminum oxide; water; hydrogen; nickel; In tetrahydrofuran; toluene;

DOI:10.1016/j.tetlet.2007.02.121

upstream raw materials:

4-nitro-1,3-dihydro-isobenzofuran

1,2-bis(bromomethyl)-3-nitrobenzene

2,3-dimethylnitrobenzene

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